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Titolo:
The design and synthesis of purine inhibitors of CDK2. III
Autore:
Shum, PW; Peet, NP; Weintraub, PM; Le, TB; Zhao, Z; Barbone, F; Cashman, B; Tsay, J; Dwyer, S; Loos, PC; Powers, EA; Kropp, K; Wright, PS; Bitonti, A; Dumont, J; Borcherding, DR;
Indirizzi:
Aventis Pharmaceut Inc, Bridgewater, NJ 08807 USA Aventis Pharmaceut Inc Bridgewater NJ USA 08807 Bridgewater, NJ 08807 USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 1067 - 1078
SICI:
1525-7770(2001)20:4-7<1067:TDASOP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASES; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Shum, PW Aventis Pharmaceut Inc, Rt 202-206, Bridgewater, NJ 08807 USA Aventis Pharmaceut Inc Rt 202-206 Bridgewater NJ USA 08807 07 USA
Citazione:
P.W. Shum et al., "The design and synthesis of purine inhibitors of CDK2. III", NUCLEOS NUC, 20(4-7), 2001, pp. 1067-1078

Abstract

Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolarinhibitors of CDK-2/cyclin E. In this report, the synthesis of a series ofpiperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:28:20