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Titolo:
Synthesis and photochemical behaviour of a T-T dimer containing an amide linkage
Autore:
Thomas, M; Clivio, P; Guillaume, D; Fourrey, JL;
Indirizzi:
CNRS, Inst Chim Chim Subst Nat, F-91198 Gif Sur Yvette, France CNRS Gif Sur Yvette France F-91198 t Nat, F-91198 Gif Sur Yvette, France Univ Picardie Jules Verne, Chim Therapeut Lab, Fac Pharm, F-80000 Amiens, France Univ Picardie Jules Verne Amiens France F-80000 , F-80000 Amiens, France
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 927 - 929
SICI:
1525-7770(2001)20:4-7<927:SAPBOA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTISENSE OLIGONUCLEOTIDES; PHOSPHODIESTER BOND; HAMMERHEAD RIBOZYME; REPLACEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Fourrey, JL CNRS, Inst Chim Chim Subst Nat, F-91198 Gif Sur Yvette, FranceCNRS Gif Sur Yvette France F-91198 98 Gif Sur Yvette, France
Citazione:
M. Thomas et al., "Synthesis and photochemical behaviour of a T-T dimer containing an amide linkage", NUCLEOS NUC, 20(4-7), 2001, pp. 927-929

Abstract

A T-T dimer characterized by an amide linkage to replace the phosphodiester backbone has been synthesized using a modified radical strategy. The new synthetic approach makes use of a thymidin-3'-yl phosphorodithioate derivative as a precursor of 3'-allyl-3'-deoxythymidine. Standard chemical transformations of this derivative led to the desired T-T dimer incorporating an amide bond. The latter was irradiated with 254 nm wavelength light to yield mainly cyclobutane and [6-4] photoadducts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:19:15