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Titolo:
Oligonucleotides with isopolar phosphonate internucleotide linkage: A new perspective for antisense compounds?
Autore:
Rejman, D; Snasel, J; Liboska, R; Tocik, Z; Paces, O; Kralikova, S; Rinnova, M; Kois, P; Rosenberg, I;
Indirizzi:
Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague 6, CzechRepublic Acad Sci Czech Republ Prague Czech Republic 6 10 Prague 6, CzechRepublic Comenius Univ, Dept Organ Chem, Bratislava, Slovakia Comenius Univ Bratislava Slovakia Dept Organ Chem, Bratislava, Slovakia
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 819 - 823
SICI:
1525-7770(2001)20:4-7<819:OWIPIL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANALOGS; DERIVATIVES; REACTIVITY; COMPLEXES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenberg, I Acad Sci Czech Republ, Inst Organ Chem & Biochem, Flemingovo Nam 2, CR-16610 Prague 6, Czech Republic Acad Sci Czech Republ Flemingovo Nam 2 Prague Czech Republic 6
Citazione:
D. Rejman et al., "Oligonucleotides with isopolar phosphonate internucleotide linkage: A new perspective for antisense compounds?", NUCLEOS NUC, 20(4-7), 2001, pp. 819-823

Abstract

Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:05:49