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Titolo:
Stacking and stability of RNA duplexes containing fluorobenzene and fluorobenzimidazole nucleosides
Autore:
Parsch, J; Engels, JW;
Indirizzi:
Univ Frankfurt, Inst Organ Chem, D-60439 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60439 hem, D-60439 Frankfurt, Germany
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 815 - 818
SICI:
1525-7770(2001)20:4-7<815:SASORD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-NITROINDOLE; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Engels, JW Univ Frankfurt, Inst Organ Chem, Marie Curie Str 11, D-60439 Frankfurt, Germany Univ Frankfurt Marie Curie Str 11 Frankfurt Germany D-60439 ny
Citazione:
J. Parsch e J.W. Engels, "Stacking and stability of RNA duplexes containing fluorobenzene and fluorobenzimidazole nucleosides", NUCLEOS NUC, 20(4-7), 2001, pp. 815-818

Abstract

Six different fluorobenzene or fluorobenzimidazole ribonucleosides and oneabasic site were incorporated in oligoribonucleotides. Individual contributions of base stacking and solvation of the modified nucleosides could be determined. In fluorobenzene . fluorobenzimidazole-modified base pairs a duplex stabilizing force was found that points to a weak F...H hydrogen bond. The lipophilicity of the unprotected nucleosides were investigated by determination of 1-octanol water partition coefficients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:59:51