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Titolo:
A new procedure for the phosphorylation of nucleosides: Application to thediscovery of inhibitors of HIV integrase
Autore:
Nair, V; Taktakishvili, M;
Indirizzi:
Univ Iowa, Dept Chem, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Iowa, Dept Chem, Iowa City, IA 52242 USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 739 - 742
SICI:
1525-7770(2001)20:4-7<739:ANPFTP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMICAL 5'-PHOSPHORYLATION; DINUCLEOTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Nair, V Univ Iowa, Dept Chem, Iowa City, IA 52242 USA Univ Iowa Iowa CityIA USA 52242 pt Chem, Iowa City, IA 52242 USA
Citazione:
V. Nair e M. Taktakishvili, "A new procedure for the phosphorylation of nucleosides: Application to thediscovery of inhibitors of HIV integrase", NUCLEOS NUC, 20(4-7), 2001, pp. 739-742

Abstract

A new phosphorylating agent for nucleosides, 2-O-(4,4'-dimethoxytrityl) ethylsulfonylethan-2'-yl-phosphate (1), has been developed by us. In the manyexamples studied by us, phosphorylation yields were found to be very high (about 90%). The procedure appears to be remarkably general and can be utilized for the phosphorylation of many biomolecules. Successful application of this phosphorylation method has contributed to the discovery of inhibitors of HIV integrase in our laboratory.

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Documento generato il 08/04/20 alle ore 11:19:10