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Titolo:
"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains
Autore:
Lobaton, E; Velazquez, S; Perez-Perez, MJ; Jimeno, ML; San-Felix, A; De Clercq, E; Balzarini, J; Camarasa, MJ;
Indirizzi:
CSIC, Inst Quim Med, E-28006 Madrid, Spain CSIC Madrid Spain E-28006CSIC, Inst Quim Med, E-28006 Madrid, Spain Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium a Inst Med Res, Louvain, Belgium
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 707 - 710
SICI:
1525-7770(2001)20:4-7<707:"GOTCD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE; INHIBITORS; NUCLEOSIDES; DERIVATIVES; PYRIMIDINE; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Camarasa, MJ CSIC, Inst Quim Med, Juan Cierva 3, E-28006 Madrid, Spain CSIC Juan Cierva 3 Madrid Spain E-28006 -28006 Madrid, Spain
Citazione:
E. Lobaton et al., ""Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains", NUCLEOS NUC, 20(4-7), 2001, pp. 707-710

Abstract

A "second generation" of TSAO molecules directed against TSAO-resistant strains have been prepared. The presence of two neighboring carbonyl groups at the 4 " position of the 3'-spiro moiety seems to be important for the anti-HIV-1 activity against both wild type and TSAO-resistant strains. NMR conformational studies in solution and theoretical calculations of the novel compounds have also been carried out.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:08:50