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Titolo:
Mechanism of inactivation of S-adenosyl-L-homocysteine hydrolase by 5 '-deoxy-5 '-S-allenylthioadenosine and 5 '-deoxy-5 '-S-propynylthioadenosine
Autore:
Guillerm, G; Guillerm, D; Witkowski-Vandenplas, C;
Indirizzi:
Univ Reims, Lab React Select & Applicat, UMR 6519, F-51687 Reims 2, FranceUniv Reims Reims France 2 & Applicat, UMR 6519, F-51687 Reims 2, France
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 685 - 688
SICI:
1525-7770(2001)20:4-7<685:MOIOSH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSYLHOMOCYSTEINE HYDROLASE; ANTIVIRAL AGENTS; INHIBITOR; ANALOGS; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Guillerm, G Univ Reims, Lab React Select & Applicat, UMR 6519, BP 1039, F-51687 Reims 2, France Univ Reims BP 1039 Reims France 2 39, F-51687 Reims 2, France
Citazione:
G. Guillerm et al., "Mechanism of inactivation of S-adenosyl-L-homocysteine hydrolase by 5 '-deoxy-5 '-S-allenylthioadenosine and 5 '-deoxy-5 '-S-propynylthioadenosine", NUCLEOS NUC, 20(4-7), 2001, pp. 685-688

Abstract

5'-Deoxy-5'-S-allenylthioadenosine 1 and 5'-deoxy-5'-S- propnylthioadenosine 2, derived from adenosine, were prepared. 1 and 2 caused irreversible inactivation of AdoHcy hydrolase. ESI mass spectra analysis of the inactivated enzyme demonstrated that 1 and 2 were type II "mechanism-based" inhibitors.

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Documento generato il 20/01/20 alle ore 07:31:37