Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anti-HBV specific beta-L-2 '-deoxynucleosides
Autore:
Bryant, ML; Bridges, EG; Placidi, L; Faraj, A; Loi, AG; Pierra, C; Dukhan, D; Gosselin, G; Imbach, JL; Hernandez, B; Juodawlkis, A; Tennant, B; Korba, B; Cote, P; Cretton-Scott, E; Schinazi, RF; Sommadossi, JP;
Indirizzi:
Novirio Pharmaceut Inc, Cambridge, MA 02476 USA Novirio Pharmaceut Inc Cambridge MA USA 02476 nc, Cambridge, MA 02476 USA Univ Alabama, Dept Pharmacol & Toxicol, Div Clin Pharmacol, Ctr Liver, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Ctr Liver, Birmingham, AL 35294 USA Novirio Pharmaceut, SARL, F-75008 Paris, France Novirio Pharmaceut ParisFrance F-75008 eut, SARL, F-75008 Paris, France Univ Montpellier 2, CNRS, UMR 5625, Chim Bioorgan Lab, F-34095 Montpellier5, France Univ Montpellier 2 Montpellier France 5 ab, F-34095 Montpellier5, France Cornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Med, Dept Clin Sci, Ithaca, NY 14853 USA Georgetown Univ, Coll Med, Div Mol Virol & Immunol, Rockville, MD 20852 USA Georgetown Univ Rockville MD USA 20852 & Immunol, Rockville, MD 20852 USA Emory Univ, Sch Med, Dept Pediat, Biochem Pharmacol Lab, Decatur, CA USA Emory Univ Decatur CA USA Pediat, Biochem Pharmacol Lab, Decatur, CA USA Vet Affairs Med Ctr, Decatur, CA USA Vet Affairs Med Ctr Decatur CA USAVet Affairs Med Ctr, Decatur, CA USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 597 - 607
SICI:
1525-7770(2001)20:4-7<597:ASB'>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-B VIRUS; MITOCHONDRIAL-DNA SYNTHESIS; HUMAN-IMMUNODEFICIENCY; NUCLEOSIDE ANALOGS; REVERSE-TRANSCRIPTASE; PHARMACOKINETIC PROPERTIES; CELLULAR PHARMACOLOGY; ANTIVIRAL ACTIVITY; POLYMERASE-GAMMA; HIV-INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Bryant, ML Novirio Pharmaceut Inc, 125 Cambridge Pk Dr, Cambridge, MA 02476 USA Novirio Pharmaceut Inc 125 Cambridge Pk Dr Cambridge MA USA 02476
Citazione:
M.L. Bryant et al., "Anti-HBV specific beta-L-2 '-deoxynucleosides", NUCLEOS NUC, 20(4-7), 2001, pp. 597-607

Abstract

A unique series of simple unnatural L-nucleosides that specifically inhibit hepatitis B virus (HBV) replication has been discovered. These molecules have in common a hydroxyl group in the 3'-position (3'-OH) of the beta -L-2'-deoxyribose sugar that confers antiviral activity specifically against hepadnaviruses. Replacement of the 3'-OH broadens activity to other viruses, Substitution in the base decreases antiviral potency and selectivity. HumanDNA polymerases and mitochondrial function are not effected. Plasma viremia is reduced up to 8 logs in a woodchuck model of chronic HBV infection. These investigational drugs, used alone or in combination, are expected to offer new therapeutic options for patients with chronic HBV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:24:42