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Titolo:
Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuranskeleton with long alkyl chains
Autore:
Sasaki, S; Shibata, T; Torigoe, H; Shibata, Y; Maeda, M;
Indirizzi:
Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Pharmaceut Sci, Fukuoka 8128582, Japan RIKEN, Tsukuba Life Sci Ctr, Tsukuba, Ibaraki, Japan RIKEN Tsukuba Ibaraki Japan sukuba Life Sci Ctr, Tsukuba, Ibaraki, Japan
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 551 - 558
SICI:
1525-7770(2001)20:4-7<551:NCODBM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANNONACEOUS ACETOGENINS; MINOR-GROOVE; ANALOGS; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, S Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Fukuoka 8128582, Japan
Citazione:
S. Sasaki et al., "Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuranskeleton with long alkyl chains", NUCLEOS NUC, 20(4-7), 2001, pp. 551-558

Abstract

Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this paper, new DNA binding molecules; diamino-bistetrahydrofuran (bisTHF) and diamino-bisfuran are reported. The bisTHF ligand with RR configuration at the amino groups and C8 alkyl chains (RR8) stabilized GC-rich duplex. In contrast, bisfuran compounds stabilized AT-rich duplex. The binding affinity of RR8 with 12 mer duplex DNA was determined by isothermal titration calorimetry to be 3.3 x 10(8) M-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:23:12