Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: Conformational tuning and high-affinity recognition of DNA/RNA targets
Autore:
Wengel, J; Petersen, M; Nielsen, KE; Jensen, GA; Hakansson, AE; Kumar, R; Sorensen, MD; Rajwanshi, VK; Bryld, T; Jacobsen, JP;
Indirizzi:
Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark Univ So Denmark Odense Denmark M k, Dept Chem, DK-5230 Odense M, Denmark Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 389 - 396
SICI:
1525-7770(2001)20:4-7<389:L(NAAT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA; DUPLEXES; ANALOGS; OLIGONUCLEOTIDE; HYBRIDIZATION; STEREOISOMERS; NMR; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Wengel, J Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark Univ So Denmark Odense Denmark M em, DK-5230 Odense M, Denmark
Citazione:
J. Wengel et al., "LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: Conformational tuning and high-affinity recognition of DNA/RNA targets", NUCLEOS NUC, 20(4-7), 2001, pp. 389-396

Abstract

The remarkable binding properties of LNA (Locked Nucleic Acid) and alpha -L-LNA (the alpha -L-ribo configured diastereoisomer of LNA) are summarized,and hybridization results for LNA/2'-O-Me-RNA chimera and LNAs with a "dangling" nucleotide are introduced. In addition, results from NMR investigations on the furanose conformations of the individual nucleotide monomers in different duplexes are presented. All these data are discussed with focus on the importance of conformational steering of unmodified nucleotides in partly modified LNA and alpha -L-LNA sequences in relation to the unprecedented binding properties of LNA and alpha -L-LNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:30:24