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Titolo:
Understanding the mode of action of L-nucleosides as antiviral agents: A molecular modeling approach
Autore:
Lee, K; Chong, YH; Chu, CK;
Indirizzi:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 aceut & Biomed Sci, Athens, GA 30602 USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 385 - 388
SICI:
1525-7770(2001)20:4-7<385:UTMOAO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV AIDS VIRUS; REVERSE-TRANSCRIPTASE; CONFORMATION; 2',3'-DIDEOXYCYTIDINE; INHIBITORS; RESISTANCE; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Chu, CK Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA30602 USA Univ Georgia Athens GA USA 30602 Biomed Sci, Athens, GA 30602 USA
Citazione:
K. Lee et al., "Understanding the mode of action of L-nucleosides as antiviral agents: A molecular modeling approach", NUCLEOS NUC, 20(4-7), 2001, pp. 385-388

Abstract

Computer modeling studies have been performed on the several pairs Of D- and L-nucleoside inhibitors with the HIV-1 RT model. Additionally, clinically important M184V mutation, which confers the viral resistance against 3TC and FTC, were studied by the same modeling system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:09:43