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Titolo:
Synthesis and anticancer activity of 4-amino-5-oxo-8-(beta-d-xylofuranosyl)pyrido[2,3-d]pyrimidine
Autore:
Pietrzkowski, Z; Girardet, JL; Esler, C; Wang, GY;
Indirizzi:
ICN Pharmaceut Inc, Chem Lab, Costa Mesa, CA 92626 USA ICN Pharmaceut IncCosta Mesa CA USA 92626 Lab, Costa Mesa, CA 92626 USA ICN Pharmaceut Inc, Canc Biol Lab, Costa Mesa, CA 92626 USA ICN PharmaceutInc Costa Mesa CA USA 92626 Lab, Costa Mesa, CA 92626 USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 323 - 328
SICI:
1525-7770(2001)20:4-7<323:SAAAO4>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ANTIBIOTIC SANGIVAMYCIN; ANALOGS; NUCLEOSIDES; TOYOCAMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, GY ICN Pharmaceut Inc, Chem Lab, 3300 Hyland Ave, Costa Mesa, CA 92626 USA ICN Pharmaceut Inc 3300 Hyland Ave Costa Mesa CA USA 92626 26 USA
Citazione:
Z. Pietrzkowski et al., "Synthesis and anticancer activity of 4-amino-5-oxo-8-(beta-d-xylofuranosyl)pyrido[2,3-d]pyrimidine", NUCLEOS NUC, 20(4-7), 2001, pp. 323-328

Abstract

4-Amino-5-OXO-8-(beta -xylofuranosyl)pyrido[2,3-d]pyrimidine (4) was recently synthesized and evaluated in our laboratories for anticancer activities. This compound showed potent in vitro inhibitory effects on the growth of HTB-81 prostate cancer cells and Daudi-lymphoma. In vivo studies showed that the compound could inhibit HTB-81 tumor growth in syngeneic mice by 93% at a daily dose of 8.5 mg/kg for 10 days.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:29:37