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Titolo:
Synthesis, hydrolysis and anti-EBV activity of a series of 3 '-modified cycloSal-BVDUMP pronucleotides
Autore:
Meier, C; Lomp, A; Meerbach, A; Wutzler, P;
Indirizzi:
Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany Univ Hamburg Hamburg Germany D-20146 rgan Chem, D-20146 Hamburg, Germany Univ Jena, Inst Antiviral Chemotherapy, D-99089 Erfurt, Germany Univ JenaErfurt Germany D-99089 l Chemotherapy, D-99089 Erfurt, Germany
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4-7, volume: 20, anno: 2001,
pagine: 307 - 314
SICI:
1525-7770(2001)20:4-7<307:SHAAAO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACYCLIC NUCLEOSIDE ANALOGS; EPSTEIN-BARR-VIRUS; ANTIVIRAL EVALUATION; NUCLEOTIDE DELIVERY; PRO-NUCLEOTIDES; HERPES-SIMPLEX; MONOPHOSPHATES; METABOLISM; SYSTEM; BYPASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Meier, C Univ Hamburg, Inst Organ Chem, Martin Luther King Pl 6, D-20146 Hamburg, Germany Univ Hamburg Martin Luther King Pl 6 Hamburg Germany D-20146 any
Citazione:
C. Meier et al., "Synthesis, hydrolysis and anti-EBV activity of a series of 3 '-modified cycloSal-BVDUMP pronucleotides", NUCLEOS NUC, 20(4-7), 2001, pp. 307-314

Abstract

A series of cycloSal-BVDUMP phosphate triesters has been prepared. The prototype compound was 3-methyl-cycloSal-BVDUMP 2. Furthermore, a series of 3'-O-acyl-modified derivatives having carboxylic acids with different lipophilicity or a L-configurated alpha -amino acid (phenylalanine) was prepared. The hydrolysis properties in phosphate buffer PBS as well as in PBS containing pig liver esterase (PLE) will be described. Finally, the biological activity against EBV has been determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:52:59