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Titolo:
Synthesis and biological activity of 4 '-C-hydroxymethyl-2 '-fluoro-D-arabinofuranosylpurine nucleosides
Autore:
Shortnacy-Fowler, AT; Tiwari, KN; Montgomery, JA; Secrist, JA;
Indirizzi:
So Res Inst, Birmingham, AL 35255 USA So Res Inst Birmingham AL USA 35255So Res Inst, Birmingham, AL 35255 USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 8, volume: 20, anno: 2001,
pagine: 1583 - 1598
SICI:
1525-7770(2001)20:8<1583:SABAO4>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
4'-SUBSTITUTED NUCLEOSIDES; EFFICIENT SYNTHESIS; 9-BETA-D-ARABINOFURANOSYLADENINE; PYRIMIDINES; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Secrist, JA So Res Inst, POB 55305, Birmingham, AL 35255 USA So Res Inst POB 55305 Birmingham AL USA 35255 am, AL 35255 USA
Citazione:
A.T. Shortnacy-Fowler et al., "Synthesis and biological activity of 4 '-C-hydroxymethyl-2 '-fluoro-D-arabinofuranosylpurine nucleosides", NUCLEOS NUC, 20(8), 2001, pp. 1583-1598

Abstract

A series of 4 ' -C-hydroxymethyl-2-fluoro-D-arabinofuranosylpurine nucleosides was prepared and evaluated for cytotoxicity. The details of a convenient synthesis of the carbohydrate precursor 4-C-hydroxymethyl-3,5-di-O-benzoyl-2-fluoro-alpha -D-arabinofuranosyl bromide (13) are presented. Proof of the structure and configuration at all chiral centers of the sugars and thenucleosides were obtained by proton NMR. All five target nucleosides were evaluated for cytotoxicity in human tumor cell lines. The 4 ' -C-hydroxymethyl clofarabine analogue (16 beta) showed slight cytotoxicity in CCRF-CEM leukemia cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:22:57