Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of the antiviral activity of hydrophobic amino acid phosphoramidate monoesters of 2 ',3 '-dideoxyadenosine (DDA) and 3 '-azido-3 '-deoxythymidine (AZT)
Autore:
Chang, SN; Griesgraber, G; Wagner, CR;
Indirizzi:
Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 d Chem, Minneapolis, MN 55455 USA Univ Minnesota, Program Microbiol Immunol & Canc Biol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 c Biol, Minneapolis, MN 55455 USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 8, volume: 20, anno: 2001,
pagine: 1571 - 1582
SICI:
1525-7770(2001)20:8<1571:COTAAO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; FEMALE B6C3F1 MICE; BIOLOGICAL-ACTIVITY; TYPE-1 ACTIVITIES; CELL-CULTURE; 2',3'-DIDEOXYINOSINE; DIDANOSINE; DECOMPOSITION; DERIVATIVES; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wagner, CR Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 neapolis, MN 55455 USA
Citazione:
S.N. Chang et al., "Comparison of the antiviral activity of hydrophobic amino acid phosphoramidate monoesters of 2 ',3 '-dideoxyadenosine (DDA) and 3 '-azido-3 '-deoxythymidine (AZT)", NUCLEOS NUC, 20(8), 2001, pp. 1571-1582

Abstract

A series of hydrophobic, water soluble and non-toxic amino acid phosphoramidate monoesters of dideoxyadenosine (ddA) and 3 ' -azido-3 ' -deoxythymidine were shown to inhibit the replication of HIV-1 in human peripheral bloodmononuclear cells PBMC from two donors. The tryptophan methyl ester phosphoramidates of AZT and ddA were equally potent (EC50S=0.3-0.40 muM), while the phenyl methyl ester of ddA was 40- to 100- fold more potent than the AZTderivatives. The alaninyl methyl ester of AZT was found to be 70- fold more potent than the ddA derivative. The methyl amide derivatives were found to be 5-20 fold less active than the methyl esters for the ddA series, whilefor AZT the derivatives were found to be of similar potency or 60- to 166-fold more potent than the methylesters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:28:48