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Titolo:
NMR studies and semi-empirical energy calculations for cyclic ADP-ribose
Autore:
Rutherford, TJ; Wilkie, J; Vu, CQ; Schnackerz, KD; Jacobson, MK; Gani, D;
Indirizzi:
Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 rmaceut Sci, Lexington, KY 40506 USA Univ Kentucky, Lucille P Markey Canc Ctr, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 ey Canc Ctr, Lexington, KY 40506 USA
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 8, volume: 20, anno: 2001,
pagine: 1485 - 1495
SICI:
1525-7770(2001)20:8<1485:NSASEC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EGG-SPECIFIC NADASE; SEA-URCHIN EGGS; CALCIUM-RELEASE; INOSITOL TRISPHOSPHATE; 2ND-MESSENGER ENZYME; SPECTROSCOPY; FERTILIZATION; PARAMETERS; METABOLITE; NAD+;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rutherford, TJ Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT land
Citazione:
T.J. Rutherford et al., "NMR studies and semi-empirical energy calculations for cyclic ADP-ribose", NUCLEOS NUC, 20(8), 2001, pp. 1485-1495

Abstract

A possible pH-dependent conformational switch was investigated for cyclic ADP-ribose. NMR signals for the exchangeable protons were observed in H2O at low temperature, but there was no direct evidence for the protonation of N-3 at neutral pH that has previously been postulated. MNDO calculations indicated that pH dependent P-31 chemical shift changes are attributable to protonation of the phosphate adjacent to the N-1 of adenine, and not due to trans-annular hydrogen bonding with a protonated N-3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:04:58