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Titolo:
Serotonin-dopamine interactions in the control of conditioned reinforcement and motor behavior
Autore:
Sasaki-Adams, DM; Kelley, AE;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Psychiat, Madison, WI 53719 USA Univ Wisconsin Madison WI USA 53719 Dept Psychiat, Madison, WI 53719 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 440 - 452
SICI:
0893-133X(200109)25:3<440:SIITCO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NUCLEUS-ACCUMBENS; DISCRIMINATIVE STIMULUS PROPERTIES; RECEPTOR MESSENGER-RNA; DORSAL RAPHE NUCLEUS; FREELY MOVING RATS; D-AMPHETAMINE; EXTRACELLULAR DOPAMINE; 5-HT3 RECEPTOR; LOCOMOTOR-ACTIVITY; PREFRONTAL CORTEX;
Keywords:
nucleus accumbens; fluoxetine; buproprion; cocaine; conditioned reinforcement; serotonin; dopamine; locomotor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Kelley, AE Univ Wisconsin, Sch Med, Dept Psychiat, 6001 Res Pk Blvd, Madison, WI 53719 USA Univ Wisconsin 6001 Res Pk Blvd Madison WI USA 53719 53719 USA
Citazione:
D.M. Sasaki-Adams e A.E. Kelley, "Serotonin-dopamine interactions in the control of conditioned reinforcement and motor behavior", NEUROPSYCH, 25(3), 2001, pp. 440-452

Abstract

These studies addressed the question of serotonin (5-HT)-dopamine (DA) interactions with regard to reward-related behavior and motor activity in rats. The first experiment evaluated the effect of chronic treatment with fluoxetine (7 mg/kg/day), a serotonin-selective reuptake inhibitor, and buproprion (15 mg/kg/day), a dopamine reuptake inhibitor, on responding for conditioned reinforcement (CR). Chronic fluoxetine, but not buproprion, enhanced CR responding, and also potentiated cocaine-induced increases in CR responding. In the second experiment, animals received intra-accumbens infusions ofeither 5-HT (0, 1, 5, and 10 mug) or DA (10, 20 mug) prior to the conditioned reinforcement test. Dopamine, but not 5-HT, selectively facilitated CR responding, although 5-HT non-specifically increased responding as well. Inthe third and fourth experiments, it was demonstrated that intra-accumbens5-HT causes increased motor activity, which was partially blocked by DA antagonists. The results suggest that chronically increased levels of 5-HT may facilitate reward related behavior, but most likely via indirect modulatory mechanisms affecting general arousal and motor tone. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 25/01/20 alle ore 19:48:28