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Titolo:
Caesarean section birth produces long term changes in dopamine D1 receptors and in stress-induced regulation of D3 and D4 receptors in the rat brain
Autore:
El-Khodor, B; Boksa, P;
Indirizzi:
McGill Univ, Res Ctr, Douglas Hosp, Dept Psychiat, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Psychiat, Verdun, PQ H4H 1R3, Canada McGill Univ, Res Ctr, Douglas Hosp, Dept Neurol & Neurosurg, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 eurosurg, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 423 - 439
SICI:
0893-133X(200109)25:3<423:CSBPLT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL BILATERAL LESION; NUCLEUS-ACCUMBENS; CESAREAN-SECTION; PERINATAL ASPHYXIA; GENERAL-ANESTHESIA; STRIATAL DOPAMINE; VAGINAL BIRTH; ADULT RATS; AUTORADIOGRAPHIC ANALYSIS; PLASMA-CORTICOSTERONE;
Keywords:
dopamine receptors; perinatal; hypoxia; caesarean section; schizophrenia; neurodevelopment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Boksa, P McGill Univ, Res Ctr, Douglas Hosp, Dept Psychiat, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada McGill Univ 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 R3, Canada
Citazione:
B. El-Khodor e P. Boksa, "Caesarean section birth produces long term changes in dopamine D1 receptors and in stress-induced regulation of D3 and D4 receptors in the rat brain", NEUROPSYCH, 25(3), 2001, pp. 423-439

Abstract

Schizophrenia is associated with increased birth complications and alteredmesocorticolimbic dopaminergic (DA) transmission, whereas stress also influences psychotic symptoms. Given this, the present study tested effects of two birth complications, Caesarean section (C-section) birth with or without acute global anoxia, on brain DA receptors in rats at adulthood. Effects of repeated stress at adulthood were also tested. Before stress, C-sectioned rats showed increased DI-like receptor binding in limbic areas, compared to vaginally born controls. There were no differences between birth groups in D2-like, D3, or D4-like receptor binding before stress. After stress, C-sectioned animals showed decreased D3 receptors in accumbens and increased D4-like receptors in dorsal striatum, accumbens, and olfactory tubercles, compared to vaginal birth. This occurred because stress upregulated D3 receptors only with vaginal birth and upregulated D4-like receptors only with C-section. Animals born by C-scction + anoxia showed no change in DA receptors relative to vaginal birth, before or after stress. It is concluded that interactions between an individual's experience of stress at adulthood, together with other environmental events in their history, such as birth complications, can be important determinants of brain DA receptor levels. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:54:05