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Titolo:
Prolactin response to dl-fenfluramine challenge before and after treatmentwith paroxetine
Autore:
Dulchin, MC; Oquendo, MA; Malone, KM; Ellis, SP; Li, SH; Mann, JJ;
Indirizzi:
New York State Psychiat Inst & Hosp, Dept Neurosci, Ctr Study Suicidal Behav, New York, NY 10032 USA New York State Psychiat Inst & Hosp New York NYUSA 10032 k, NY 10032 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 395 - 401
SICI:
0893-133X(200109)25:3<395:PRTDCB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-HUMAN SUBJECTS; MAJOR DEPRESSION; SEROTONERGIC RESPONSIVITY; PLACEBO CHALLENGE; PLASMA PROLACTIN; ANTIDEPRESSANT TREATMENT; CORTISOL RESPONSES; HORMONE RESPONSES; SSRI TREATMENT; RELEASE;
Keywords:
fenfluramine challenge; serotonin; depression; pharmacologic treatment; paroxetine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Dulchin, MC New York State Psychiat Inst & Hosp, Dept Neurosci, Ctr Study Suicidal Behav, Box 105,1051 Riverside Dr, New York, NY 10032 USA New York State Psychiat Inst & Hosp Box 105,1051 Riverside Dr New York NY USA 10032
Citazione:
M.C. Dulchin et al., "Prolactin response to dl-fenfluramine challenge before and after treatmentwith paroxetine", NEUROPSYCH, 25(3), 2001, pp. 395-401

Abstract

The prolactin response to dl-fenfluramine (an indirect central serotonin agonist) challenge has been used to assess serotonergic function and appearsto be blunted in depressed patients. We used this method to determine whether the serotonergic deficit in depressed patients is corrected by treatment with paroxetine. Prior to treatment with paroxetine sixteen depressed patients received a placebo challenge followed by a dl-fenfluramine challenge the next day. The same two challenges were repeated after treatment. Prolactin baseline levels were measured before pill administration, and then hourly for 5 hours. Fenfluramine/ norfenfluramine levels were assayed at each time point after drug administration. Treatment with paroxetine significantly increased the baseline prolactin level independently of treatment response but positively correlated with paroxetine dose. We found that pre-treatment prolactin response to dl-fenfluramine challenge did not predict clinicalresponse to paroxetine, nor did the prolactin response change significantly after treatment. There was no significant difference in the post-treatment prolactin response between treatment responders and treatment non-responders. We found evidence of increased prolactin levels that may reflect effects of paroxetine in enhancing serotonin levels. Acute release of serotonin as measured by the prolactin response to fenfluramine is not altered by paroxetine treatment. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:54:41