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Titolo:
Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats
Autore:
Highfield, D; Yap, J; Grimm, JW; Shalev, U; Shaham, Y;
Indirizzi:
NIDA, Behav Neurosci Branch, IRP, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 sci Branch, IRP, NIH, Baltimore, MD 21224 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 320 - 331
SICI:
0893-133X(200109)25:3<320:RLTASB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR DOPAMINE LEVELS; SELF-ADMINISTRATION BEHAVIOR; NUCLEUS-ACCUMBENS; NORADRENERGIC NEURONS; ADMINISTERED COCAINE; INTRAVENOUS COCAINE; CONDITIONED CHANGES; INDUCED RELAPSE; RHESUS-MONKEYS; ANIMAL-MODEL;
Keywords:
alpha-2 adrenoceptor agonists; cocaine; drug self-administration; extinction; heroin; reinstatement; relapse; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Shaham, Y NIDA, Behav Neurosci Branch, IRP, NIH, 5500 Nathan Shock Dr, Baltimore, MD21224 USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 re, MD21224 USA
Citazione:
D. Highfield et al., "Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats", NEUROPSYCH, 25(3), 2001, pp. 320-331

Abstract

Alpha-2 adrenoceptor agonists (lofexidine, clonidine) are used to alleviate short-term opioid withdrawal in humans. In rats, acute injections of these agents attenuate stress-induced reinstatement of heroin and cocaine seeking at time points that are beyond the acute drug withdrawal phase. Here, westudied whether exposure to lofexidine would attenuate reinstatement of a heroin-cocaine mixture (speedball) seeking induced by exposure to stress orto drug-associated cues. Rats were trained to lever press for speedball for 10 days, and the drug-reinforced behavior was then extinguished for 11 days in the presence (Experiment 1) or the absence (Experiment 2) of the drugcues. Subsequently, rats were tested for reinstatement of drug seeking after exposure to intermittent footshock stress (5-15 min; Experiment 1) or the drug cues (Experiment 2). Starting on day 7 of training, rats received daily injections of saline or lofexidine (0.1 or 0.2 mg/kg). Repeated lofexidine treatment significantly attenuated footshock-induced reinstatement, butdid not alter drug cues-induced reinstatement of speedball seeking. fit addition, lofexidine did not have a consistent effect on speedball self-administration and extinction behavior. Results extend previous reports with acute drug injections, indicating that lofexidine maintains its effect on stress-induced reinstatement after repeated treatment. The present data also suggest that the neurochemical events underlying stress- and drug cues-induced relapse are not identical. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 02/04/20 alle ore 01:55:55