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Titolo:
Emergence of input specificity of LTP during development of retinotectal connections in vivo
Autore:
Tao, HZW; Zhang, LI; Engert, F; Poo, MM;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA
Titolo Testata:
NEURON
fascicolo: 4, volume: 31, anno: 2001,
pagine: 569 - 580
SICI:
0896-6273(20010830)31:4<569:EOISOL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; DEPENDENT SYNAPTIC PLASTICITY; HIPPOCAMPAL PYRAMIDAL NEURONS; PROPAGATING ACTION-POTENTIALS; GATED CA2+ CHANNELS; DENDRITIC SPINES; NMDA RECEPTORS; CALCIUM INFLUX; NEURAL NETWORKS; SLICE CULTURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Poo, MM Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 229 Stanley Hall Berkeley CA USA 94720 720 USA
Citazione:
H.Z.W. Tao et al., "Emergence of input specificity of LTP during development of retinotectal connections in vivo", NEURON, 31(4), 2001, pp. 569-580

Abstract

Input specificity of activity-induced synaptic modification was examined in the developing Xenopus retinotectal connections. Early in development, long-term potentiation (LTP) induced by theta burst stimulation (TBS) at one retinal input spreads to other unstimulated converging inputs on the same tectal neuron. As the animal develops, LTP induced by the same TBS becomes input specific, a change that correlates with the increased complexity of tectal dendrites, and more restricted distribution of dendritic Ca2+ evoked by each retinal input. In contrast, LTP induced by 1 Hz correlated pre- and postsynaptic spiking is input specific throughout the same developmental period. Thus, input specificity of LTP emerges with neural development and depends on the pattern of synaptic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:31:13