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Titolo:
Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation
Autore:
Solecki, DJ; Liu, XL; Tomoda, T; Fang, Y; Hatten, ME;
Indirizzi:
Rockefeller Univ, Dev Neurobiol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 robiol Lab, New York, NY 10021 USA
Titolo Testata:
NEURON
fascicolo: 4, volume: 31, anno: 2001,
pagine: 557 - 568
SICI:
0896-6273(20010830)31:4<557:ANSIDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-HELIX FACTORS; BHLH GENE HES1; SONIC HEDGEHOG; NERVOUS-SYSTEM; CELL-PROLIFERATION; MOUSE-BRAIN; NEUROGENESIS; EXPRESSION; SPECIFICATION; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Hatten, ME Rockefeller Univ, Dev Neurobiol Lab, 1230 York Ave, New York, NY 10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 10021 USA
Citazione:
D.J. Solecki et al., "Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation", NEURON, 31(4), 2001, pp. 557-568

Abstract

In the developing cerebellar cortex, granule neuron precursors (GNPs) proliferate and commence differentiation in a superficial zone, the external granule layer (EGL). The molecular basis of the transition from proliferatingprecursors to immature differentiating neurons remains unknown. Notch signaling is an evolutionarily conserved pathway regulating the differentiationof precursor cells of many lineages. Notch2 is specifically expressed in proliferating GNPs in the EGL. Treatment of GNPs with soluble Notch ligand Jagged1, or overexpression of activated Notch2 or its downstream target HES1, maintains precursor proliferation. The addition of GNP mitogens Jagged1 or Sonic Hedgehog (Shh) upregulates the expression of HES1, suggesting a role for HES1 in maintaining precursor proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:15:17