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Titolo:
Language mapping in less than 15 minutes: Real-time functional MRI during routine clinical investigation
Autore:
Fernandez, G; de Greiff, A; von Oertzen, J; Reuber, M; Lun, S; Klaver, P; Ruhlmann, J; Reul, JD; Elger, CE;
Indirizzi:
Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 nn, Dept Epileptol, D-53105 Bonn, Germany Med Ctr Bonn, Dept Diagnost & Therapeut Neuroradiol, D-53119 Bonn, GermanyMed Ctr Bonn Bonn Germany D-53119 eut Neuroradiol, D-53119 Bonn, Germany
Titolo Testata:
NEUROIMAGE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 585 - 594
SICI:
1053-8119(200109)14:3<585:LMILT1>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL STIMULATION; HUMAN BRAIN; WADA TEST; DOMINANCE; LOCALIZATION; IMAGE; FMRI; ACTIVATION; EPILEPSY; LATERALIZATION;
Keywords:
language lateralization; fMRI; online analysis; epilepsy surgery; neurosurgery; synonym task;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez, G Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 eptol, D-53105 Bonn, Germany
Citazione:
G. Fernandez et al., "Language mapping in less than 15 minutes: Real-time functional MRI during routine clinical investigation", NEUROIMAGE, 14(3), 2001, pp. 585-594

Abstract

Neurosurgical interventions often require the presurgical determination oflanguage dominance or mapping of language areas. Results obtained by fMRI are closely correlated with invasive procedures such as electrical stimulation mapping or the intracarotid amobarbital test. However, language fMRI isnot used routinely, because postprocessing is time-consuming. We utilized a real-time analysis software installed directly on the AM console computerand SPM99 as reference postprocessing software. We assessed the reliability of the immediate determination of language dominance based on individual activation maps by comparing the results of the visual analysis of images derived from conventional postprocessing with those produced by the real-time tool. All images were rated independently by six senior neurologists blinded to other data. We validated the robustness of the realtime method statistically by comparing global and regional lateralization indices derived from real-time and postprocessing analysis. Functional MRI was performed witha standard 1.5-T whole-body scanner. Brain activity was contrasted betweenan alternating semantic judgment and letter matching task. Twelve right-handed, healthy control subjects and 12 consecutive patients with drug-resistant, localization-related epilepsy were investigated. The semantic condition induced almost invariably left hemispheric activations in Broca's area, the premotor cortex, the dorsolateral prefrontal cortex, and the temporoparietal region. Although real-time analysis reduced noise less effectively than SPM99, visual ratings and lateralization indices produced highly concordant results with both methods. In conclusion, real-time MRI, as used here, allowed reliable language lateralization and mapping in less than 15 min during routine clinical MRI investigation with no need for postprocessing. (C)2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:19:06