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Titolo:
Statistical analysis of hippocampal asymmetry in schizophrenia
Autore:
Wang, L; Joshi, SC; Miller, MI; Csernansky, JG;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Metropolitan St Louis Psychiat Ctr, St Louis, MO 63130 USA Metropolitan StLouis Psychiat Ctr St Louis MO USA 63130 is, MO 63130 USA Johns Hopkins Univ, Whiting Sch Engn, Ctr Imaging Sci, Baltimore, MD 21218USA Johns Hopkins Univ Baltimore MD USA 21218 ing Sci, Baltimore, MD 21218USA Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA ept Radiat Oncol, Chapel Hill, NC USA Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA Dept Biomed Engn, Chapel Hill, NC USA
Titolo Testata:
NEUROIMAGE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 531 - 545
SICI:
1053-8119(200109)14:3<531:SAOHAI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; HEMISPHERIC-ASYMMETRY; CEREBRAL HEMISPHERES; ALZHEIMERS-DISEASE; PLANUM-TEMPORALE; NORMAL PERSONS; HUMAN-BRAIN; MRI; MORPHOMETRY; DISORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, L Washington Univ, Sch Med, Dept Psychiat, Campus Box 8134,660 S Euclid Ave,St Louis, MO 63110 USA Washington Univ Campus Box 8134,660 S EuclidAve St Louis MO USA 63110
Citazione:
L. Wang et al., "Statistical analysis of hippocampal asymmetry in schizophrenia", NEUROIMAGE, 14(3), 2001, pp. 531-545

Abstract

The asymmetry of brain structures has been studied in schizophrenia to better understand its underlying neurobiology. Brain regions of interest have previously been characterized by volumes, cross-sectional and surface areas, and lengths. Using high-dimensional brain mapping, we have developed a statistical method for analyzing patterns of left-right asymmetry of the human hippocampus taken from high-resolution MR scans. We introduce asymmetry measures that capture differences in the patterns of high-dimensional vectorfields between the left and right hippocampus surfaces. In 15 pairs of subjects previously studied (J. G. Csernansky et al., 1998, Proc. Natl. Acad. Sci. USA 95, 11406-11411). we define the difference in hippocampal asymmetry patterns between the groups. Volume analysis indicated a large normative asymmetry between left and right hippocampus (R > L), and shape analysis allowed us to visualize the normative asymmetry pattern of the hippocampal surfaces. We observed that the right hippocampus was wider along its lateral side in both schizophrenia and control subjects. Also, while patterns of hippocampal asymmetry were generally similar in the schizophrenia and controlgroups, a principal component analysis based on left-right asymmetry vector fields detected a statistically significant difference between the two groups, specifically related to the subiculum. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:25:09