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Titolo:
Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning
Autore:
Malin, DH; Crothers, MK; Lake, JR; Goyarzu, P; Plotner, RE; Garcia, SA; Spell, SH; Tomsic, BJ; Giordano, T; Kowall, NW;
Indirizzi:
Univ Houston Clear Lake City, Houston, TX 77058 USA Univ Houston Clear Lake City Houston TX USA 77058 , Houston, TX 77058 USA Message Pharmaceut Inc, Malvern, PA 19355 USA Message Pharmaceut Inc Malvern PA USA 19355 ut Inc, Malvern, PA 19355 USA Vet Adm Med Ctr, Bedford, MA 01730 USA Vet Adm Med Ctr Bedford MA USA 01730 t Adm Med Ctr, Bedford, MA 01730 USA Boston Univ, Sch Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 oston Univ, Sch Med, Boston, MA 02118 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 2, volume: 76, anno: 2001,
pagine: 125 - 137
SICI:
1074-7427(200109)76:2<125:HIOAB1>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCES ONE-TRIAL; RAT-BRAIN; ALZHEIMERS-DISEASE; CORTICAL-NEURONS; AGED RATS; MEDIAL SEPTUM; IN-VITRO; PROTEIN; MEMORY; NEUROTOXICITY;
Keywords:
amyloid beta-peptides; hippocampus; reward learning; memory impairment; neurodegeneration; Alzheimer's disease; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Malin, DH Univ Houston Clear Lake City, Box 237,2700 Bay Area Blvd, Houston, TX 77058 USA Univ Houston Clear Lake City Box 237,2700 Bay Area Blvd Houston TX USA 77058
Citazione:
D.H. Malin et al., "Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning", NEUROBIOL L, 76(2), 2001, pp. 125-137

Abstract

The injection of amyloid beta -peptide (A beta) into rat CNS has been reported to induce cellular neuropathology. The present study investigated whether multiple intrahippocampal injections of A beta 1-40 would impair one-trial/day reward learning 14 days later. Twenty-four male Sprague-Dawley rats, 3-4 months old, were injected with either A beta 1-40 or distilled water into seven hippocampal sites bilaterally. Ten rats received 3 nmol A beta 1-40 in 2 mul of distilled water per injection site, while 14 rats received distilled water alone. Following a 9-day recovery period, rats were gradually food deprived to 82% of their initial body weight. Fourteen days after the intrahippocampal injection, all rats received an initial training trial and three subsequent daily retention trials. Rats receiving A beta 1-40 were significantly impaired on the second retention trial in terms of accuracy(number of unbaited alleys entered) and on the second and third retention trials in terms of speed (reciprocal of latency to reward). Histological analysis showed that A beta 1-40 injections produced significant neuronal loss and gliosis. A beta 1-40 immunoreactivity persisted locally at the injection site and in macrophages 2 weeks following the hippocampal injections. These effects appear to be sequence-specific; rats receiving A beta 1-42 with a scrambled peptide sequence did not differ significantly from rats receiving distilled water alone in retention of the learning task or degree of histological damage. (C) 2001 Academic Press.

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Documento generato il 02/04/20 alle ore 01:43:51