Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Subunit-specific temporal and spatial patterns of AMPA receptor exocytosisin hippocampal neurons
Autore:
Passafaro, M; Piech, V; Sheng, M;
Indirizzi:
Massachusetts Gen Hosp, Dept Neurobiol, Boston, MA 02114 USA MassachusettsGen Hosp Boston MA USA 02114 eurobiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Howard Hughes Med Inst, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Med Inst, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 vard Univ, Sch Med, Boston, MA 02114 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 9, volume: 4, anno: 2001,
pagine: 917 - 926
SICI:
1097-6256(200109)4:9<917:STASPO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; DOMAIN-CONTAINING PROTEINS; GLUTAMATE RECEPTORS; SYNAPTIC PLASTICITY; BREFELDIN-A; MEMBRANE; SYNAPSES; GLUR2; LTP; REDISTRIBUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Sheng, M MIT, Ctr Learning & Memory, E18-215,77 Massachusetts Ave, Cambridge, MA 02139 USA MIT E18-215,77 Massachusetts Ave Cambridge MA USA 02139 02139 USA
Citazione:
M. Passafaro et al., "Subunit-specific temporal and spatial patterns of AMPA receptor exocytosisin hippocampal neurons", NAT NEUROSC, 4(9), 2001, pp. 917-926

Abstract

Using a thrombin cleavage assay in cultured hippocampal neurons, we studied the kinetics, regulation and site of AMPA receptor surface delivery. Surface insertion of the GluR1 subunit occurs slowly in basal conditions and isstimulated by NMDA receptor activation and insulin, whereas GluR2 exocytosis is constitutively rapid. Although both subunits ultimately concentrate in synapses, GluR1 and GluR2 show different spatial patterns of surface accumulation, consistent with GluR1 being inserted initially at extrasynaptic sites and GluR2 being inserted more directly at synapses. The spatiotemporalpattern of surface accumulation is determined by the cytoplasmic tails of GluR subunits, and in heteromeric receptors, GluR1 acts dominantly over GluR2. We propose that GluR1 controls the exocytosis and GluR2/3, the recycling and endocytosis of AMPA receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:39:35