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Titolo:
GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1
Autore:
Bedford, FK; Kittler, JT; Muller, E; Thomas, P; Uren, JM; Merlo, D; Wisden, W; Triller, A; Smart, TG; Moss, SJ;
Indirizzi:
Univ Coll London, MRC, Mol Cell Biol Lab, London WC1E 6BT, England Univ Coll London London England WC1E 6BT l Lab, London WC1E 6BT, England Univ Coll London, Dept Pharmacol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT macol, London WC1E 6BT, England INSERM, U497, Dept Biol, Lab Biol Cellulaire Synapse, F-75005 Paris, France INSERM Paris France F-75005 ol Cellulaire Synapse, F-75005 Paris, France Univ London Sch Pharm, Dept Pharmacol, London WC1E 1AX, England Univ London Sch Pharm London England WC1E 1AX , London WC1E 1AX, England MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH , Mol Biol Lab, Cambridge CB2 2QH, England
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 9, volume: 4, anno: 2001,
pagine: 908 - 916
SICI:
1097-6256(200109)4:9<908:GRCSNA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; HIPPOCAMPAL-NEURONS; GAMMA-2 SUBUNIT; A RECEPTORS; AMPA RECEPTORS; BETA SUBUNITS; SYNAPSES; IDENTIFICATION; ENDOCYTOSIS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Moss, SJ Univ Coll London, MRC, Mol Cell Biol Lab, Gower St, London WC1E 6BT, England Univ Coll London Gower St London England WC1E 6BT E 6BT, England
Citazione:
F.K. Bedford et al., "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1", NAT NEUROSC, 4(9), 2001, pp. 908-916

Abstract

Controlling the number of functional gamma -aminobutyric acid A (GABA(A)) receptors in neuronal membranes is a crucial factor for the efficacy of inhibitory neurotransmission. Here we describe the direct interaction of GABA(A) receptors with the ubiquitin-like protein Plic-1. Furthermore, Plic-1 isenriched at inhibitory synapses and is associated with subsynaptic membranes. Functionally, Plic-1 facilitates GABA(A) receptor cell surface expression without affecting the rate of receptor internalization. Plic-1 also enhances the stability of intracellular GABA(A) receptor subunits, increasing the number of receptors available for insertion into the plasma membrane. Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:18:39