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Titolo:
A cellular mechanism of reward-related learning
Autore:
Reynolds, JNJ; Hyland, BI; Wickens, JR;
Indirizzi:
Univ Otago, Sch Med Sci, Neurosci Res Ctr, Dunedin, New Zealand Univ Otago Dunedin New Zealand , Neurosci Res Ctr, Dunedin, New Zealand Univ Otago, Sch Med Sci, Dept Anat & Struct Biol, Dunedin, New Zealand Univ Otago Dunedin New Zealand Anat & Struct Biol, Dunedin, New Zealand Univ Otago, Sch Med Sci, Dept Physiol, Dunedin, New Zealand Univ Otago Dunedin New Zealand Sci, Dept Physiol, Dunedin, New Zealand
Titolo Testata:
NATURE
fascicolo: 6851, volume: 413, anno: 2001,
pagine: 67 - 70
SICI:
0028-0836(20010906)413:6851<67:ACMORL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-POTENTIAL FLUCTUATIONS; NIGROSTRIATAL DOPAMINE SYSTEM; VENTRAL TEGMENTAL AREA; SELF-STIMULATION; SPINY NEURONS; IN-VIVO; BRAIN-STIMULATION; RAT NEOSTRIATUM; NEURAL-NETWORK; BASAL GANGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wickens, JR Univ Otago, Sch Med Sci, Neurosci Res Ctr, Dunedin, New Zealand Univ Otago Dunedin New Zealand es Ctr, Dunedin, New Zealand
Citazione:
J.N.J. Reynolds et al., "A cellular mechanism of reward-related learning", NATURE, 413(6851), 2001, pp. 67-70

Abstract

Positive reinforcement helps to control the acquisition of learned behaviours. Here we report a cellular mechanism in the brain that may underlie thebehavioural effects of positive reinforcement. We used intracranial self-stimulation (ICSS) as a model of reinforcement learning(1), in which each rat learns to press a lever that applies reinforcing electrical stimulation to its own substantia nigra(2,3). The outputs from neurons of the substantianigra terminate on neurons in the striatum in close proximity to inputs from the cerebral cortex on the same striatal neurons(4). We measured the effect of substantia nigra stimulation on these inputs from the cortex to striatal neurons and also on how quickly the rats learned to press the lever. We found that stimulation of the substantia nigra (with the optimal parameters for lever-pressing behaviour) induced potentiation of synapses between the cortex and the striatum, which required activation of dopamine receptors. The degree of potentiation within ten minutes of the ICSS trains was correlated with the time taken by the rats to learn ICSS behaviour.

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Documento generato il 12/08/20 alle ore 20:53:53