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Titolo:
The role of bile acids in carcinogenesis
Autore:
Debruyne, PR; Bruyneel, EA; Li, XD; Zimber, A; Gespach, C; Mareel, MM;
Indirizzi:
State Univ Ghent Hosp, Dept Radiotherapy & Nucl Med, Expt Cancerol Lab, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 ol Lab, B-9000 Ghent, Belgium Hop St Antoine, INSERM U482, F-75571 Paris 12, France Hop St Antoine Paris France 12 ne, INSERM U482, F-75571 Paris 12, France
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
, volume: 480, anno: 2001,
pagine: 359 - 369
SICI:
1386-1964(20010901)480:<359:TROBAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; COLON-CANCER CELLS; FAMILIAL ADENOMATOUS POLYPOSIS; COLORECTAL-CANCER; LITHOCHOLIC ACID; DEOXYCHOLIC-ACID; NUCLEAR RECEPTOR; BREAST-CANCER; CYCLOOXYGENASE-2 EXPRESSION; INTRARECTAL INSTILLATION;
Keywords:
bile acids; carcinogenesis; invasion; signaling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Mareel, MM State Univ Ghent Hosp, Dept Radiotherapy & Nucl Med, Expt Cancerol Lab, 1P7,De Pintelaan 185, B-9000 Ghent, Belgium State Univ Ghent Hosp 1P7,De Pintelaan 185 Ghent Belgium B-9000
Citazione:
P.R. Debruyne et al., "The role of bile acids in carcinogenesis", MUT RES-F M, 480, 2001, pp. 359-369

Abstract

dBile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and experimental studies. Some bile acids stimulate growth of normal colonic and adenoma cells, but not of colorectal cancer cells. Moreover, bile acids stimulate invasion of colorectal. cancer cells, at least in vitro. One possible mechanism of action is bile acid-induced DNA binding andtransactivation of the activator protein-1 (AP-1) by co-operate activationof extracellular signal-regulated kinases (ERKs) and PKC signaling. In thepresent paper, we review the mechanisms by which bile acids influence carcinogenesis. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:49:00