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Titolo:
Inhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassia
Autore:
Sharma, N; Trikha, P; Athar, M; Raisuddin, S;
Indirizzi:
Jamia Hamdard Univ, Dept Med Elementol & Toxicol, New Delhi 110062, India Jamia Hamdard Univ New Delhi India 110062 xicol, New Delhi 110062, India
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
, volume: 480, anno: 2001,
pagine: 179 - 188
SICI:
1386-1964(20010901)480:<179:IOBACM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-S-TRANSFERASE; BONE-MARROW; EMBLICA-OFFICINALIS; ESCHERICHIA-COLI; RAT-LIVER; MICE; CINNAMALDEHYDE; DAMAGE; CYCLOPHOSPHAMIDE; OCCIDENTALIS;
Keywords:
Cinnamomum cassia; antimutagenicity; Ames test; chromosomal aberrations; micronuclei; chemoprevention; xenobiotic metabolizing enzymes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Raisuddin, S Jamia Hamdard Univ, Dept Med Elementol & Toxicol, New Delhi 110062, India Jamia Hamdard Univ New Delhi India 110062 lhi 110062, India
Citazione:
N. Sharma et al., "Inhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassia", MUT RES-F M, 480, 2001, pp. 179-188

Abstract

Cinnamomum cassia is used as a flavoring spice with some established medicinal properties. In this study, we evaluated the antimutagenic effect of C.cassia against two mutagens, viz. benzo[a]pyrene (B[a]P) and cyclophosphamide (CP). The antimutagenic properties of C cassia were examined by the Ames test. In vivo chromosomal aberration (CA) and micronuclei tests were alsoemployed to assess the antimutagenic effect of C. cassia in mice after pretreatment with the extract orally for seven consecutive days. To elucidate the mechanism by which C. cassia exerts its antimutagenic effect, certain key enzymes involved in bioactivation and detoxification processes were alsoinvestigated. Changes in liver cytochrome P450 (Cyt P450), glutathione content (GSH), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPX) were evaluated in pretreated animals. It wasobserved in the Ames test, bone marrow chromosomal aberration assay, and micronucleus test that C cassia exerted significant antimutagenic effects against B[a]P and CP in animals treated with the plant extract. C cassia pretreatment decreased Cyt P450 content but increased GSH content and the activity of glutathione-de pendent antioxidant enzymes, viz. GST, GR, and GPX. The present findings demonstrate that the antimutagenic potential of C. cassia could be attributed to its modulatory effect on the xenobiotic bioactivation and detoxification processes. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:30:29