Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Impact of bacteria in dairy products and of the intestinal microflora on the genotoxic and carcinogenic effects of heterocyclic aromatic amines
Autore:
Knasmuller, S; Steinkellner, H; Hirschl, AM; Rabot, S; Nobis, EC; Kassie, F;
Indirizzi:
Univ Vienna, Canc Res Inst, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Canc Res Inst, A-1090 Vienna, Austria Univ Vienna, Inst Microbiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Inst Microbiol, A-1090 Vienna, Austria INRA, Jouy En Josas, France INRA Jouy En Josas FranceINRA, Jouy En Josas, France
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
, volume: 480, anno: 2001,
pagine: 129 - 138
SICI:
1386-1964(20010901)480:<129:IOBIDP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACTIC-ACID BACTERIA; URINARY MUTAGENICITY; GUT MICROFLORA; FOOD MUTAGEN; GERM-FREE; RATS; METABOLISM; IQ; BINDING; FLORA;
Keywords:
heterocyclic aromatic amines; genotoxicity; carcinogenicity; intestinal bacteria; lactic bacilli;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Knasmuller, S Univ Vienna, Canc Res Inst, Borschkegasse 8A, A-1090 Vienna,Austria Univ Vienna Borschkegasse 8A Vienna Austria A-1090 Austria
Citazione:
S. Knasmuller et al., "Impact of bacteria in dairy products and of the intestinal microflora on the genotoxic and carcinogenic effects of heterocyclic aromatic amines", MUT RES-F M, 480, 2001, pp. 129-138

Abstract

This article gives a short overview on the present state of knowledge of the effects of the intestinal microflora on the health hazards of heterocyclic aromatic amines (HAs). Results of single cell gel electrophoresis assayswith conventional, germ free and human flora associated rats indicate thatthe presence of intestinal microorganisms strongly enhances the induction of DNA-damage in colon and liver cells by IQ. Furthermore, it was found that supplementation of the feed with Lactobacilli attenuates the induction ofcolon cancer by this same amine. These recent findings suggest that the intestinal microflora and lactic acid bacilli in dairy products strongly affect the health risks of HAs. Nevertheless, most previous experiments with HAs focused on the involvement of mammalian enzymes in the biotransformation of these compounds and only a few articles are available which concern interactions of bacteria with HAs. Some of these studies suggested that the formation of directly mutagenic hydroxy-metabolites of the amines by fecal bacteria might be an important activation pathway but it turned out that the hydroxy-derivative of IQ is not genotoxic in mammalian cells and does not cause colon cancer in laboratory rodents. There is some evidence that hydrolysis of HA-metabolites by bacterial beta -glucuronidase might play a role inthe activation of HAs but experimental data are scarce and no firm conclusions can be drawn at present. The most important detoxification mechanism appears to be the direct binding of the HAs to the cell walls of certain bacterial strains contained in fermented foods. It was shown that these effects do also take place under physiologically relevant conditions. Overall, itseems that intestinal bacteria play a key role in the activation and detoxification of HAs which has been an area of research long ignored. The elucidation of these mechanisms may enable the development of biomarkers for colon cancer risk and nutritional strategies of protection. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:14:58