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Titolo:
Recommended dietary allowances (RDAs) for genomic stability
Autore:
Fenech, M;
Indirizzi:
CSIRO, Adelaide, SA 5000, Australia CSIRO Adelaide SA Australia 5000CSIRO, Adelaide, SA 5000, Australia
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
, volume: 480, anno: 2001,
pagine: 51 - 54
SICI:
1386-1964(20010901)480:<51:RDA
Fonte:
ISI
Lingua:
ENG
Soggetto:
URACIL MISINCORPORATION; POSTMENOPAUSAL WOMEN; CHROMOSOME BREAKAGE; FOLATE-DEFICIENCY; DNA-DAMAGE; DEPLETION; POLYMORPHISMS; HOMOCYSTEINE; LYMPHOCYTES; PREVENTION;
Keywords:
RDA; recommended dietary allowance; diet; vitamins; micronutrients; genomic stability; DNA damage; micronucleus; DNA methylation; DNA strand breaks; chromosome aberrations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Fenech, M CSIRO, POB 10041,Gouger St, Adelaide, SA 5000, Australia CSIRO POB 10041,Gouger St Adelaide SA Australia 5000 , Australia
Citazione:
M. Fenech, "Recommended dietary allowances (RDAs) for genomic stability", MUT RES-F M, 480, 2001, pp. 51-54

Abstract

Diet as a key factor in determining genomic stability is more important than previously imagined because we now know it impacts on all relevant pathways, i.e. exposure to dietary carcinogens, activation/detoxification of carcinogens, DNA repair, DNA synthesis and apoptosis. Current recommended dietary allowances for vitamins and minerals are based largely on the prevention of diseases of deficiency such as scurvy in the case of Vitamin C. Because diseases of development, degenerative disease and ageing itself are partly caused by damage to DNA, it seems logical that we should focus better ourattention on defining optimal requirements of key minerals and vitamins for preventing damage to both nuclear and mitochondrial DNA. To date our knowledge on optimal micronutrient levels for genomic stability is scanty and disorganised. Appropriately designed placebo, controlled trials are requiredto define recommended dietary allowances for genomic stability. Recently, it has been shown that above RDA intakes of folic acid and Vitamin B12 are required to reduce the micronucleus index in humans by 25%. In the future, clinical trials with a defined wider array of complementary DNA damage end-points would be necessary. That there is a need for an international collaborative group to establish RDAs for genomic stability is self-evident and this paper is a call for such a process to begin. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:27:15