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Titolo:
Genomic integrity and the repair of double-strand DNA breaks
Autore:
Pastink, A; Eeken, JCJ; Lohman, PHM;
Indirizzi:
Dept Radiat Genet & Chem Mutagenesis, Sylvius Lab, NL-2333 AL Leiden, Netherlands Dept Radiat Genet & Chem Mutagenesis Leiden Netherlands NL-2333 AL lands
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
, volume: 480, anno: 2001,
pagine: 37 - 50
SICI:
1386-1964(20010901)480:<37:GIATRO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPLICATION PROTEIN-A; HUMAN RAD51 PROTEIN; GROSS CHROMOSOMAL REARRANGEMENTS; SEVERE COMBINED IMMUNODEFICIENCY; SCHIZOSACCHAROMYCES-POMBE RAD32; XENOPUS-LAEVIS OOCYTES; END-JOINING PATHWAY; RECA-LIKE GENE; MOUSE L-CELLS; SACCHAROMYCES-CEREVISIAE;
Keywords:
genomic integrity; double-strand breaks; homologous recombination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
165
Recensione:
Indirizzi per estratti:
Indirizzo: Pastink, A Dept Radiat Genet & Chem Mutagenesis, Sylvius Lab, Wassenaarseweg 72, NL-2333 AL Leiden, Netherlands Dept Radiat Genet & Chem Mutagenesis Wassenaarseweg 72 Leiden Netherlands NL-2333 AL
Citazione:
A. Pastink et al., "Genomic integrity and the repair of double-strand DNA breaks", MUT RES-F M, 480, 2001, pp. 37-50

Abstract

The induction of double-strand breaks (DSBs) in DNA by exposure to DNA damaging agents or as inter-mediates in normal cellular processes, creates a severe threat for the integrity of the genome. Unrepaired or incorrectly repaired DSBs lead to broken chromosomes and/or gross chromosomal rearrangements which are frequently associated with tumor formation in mammals. To maintain the integrity of the genome and to prevent the formation of chromosomal aberrations, several pathways exist in eukaryotes: homologous recombination (HR), non-homologous end joining (NHEJ) and single-strand annealing (SSA). These mechanisms are conserved in evolution, but the relative contribution depends on the organism, cell type and stage of the cell cycle. In yeast, DSBs are primarily repaired via HR while in higher eukaryotes, both HR and NHEJ are important. In mammals, defects in both HR or NHEJ lead to a predisposition to cancer and at the cellular level, the frequency of chromosomal aberrations is increased. This review summarizes our current knowledge about DSB-repair with emphasis on recent progress in understanding the precise biochemical activities of individual proteins involved. (C) 2001 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:43:17