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Titolo:
Antimutagenesis and anticarcinogenesis, from the past to the future
Autore:
Weisburger, JH;
Indirizzi:
Amer Hlth Fdn, Valhalla, NY 10595 USA Amer Hlth Fdn Valhalla NY USA 10595Amer Hlth Fdn, Valhalla, NY 10595 USA
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
, volume: 480, anno: 2001,
pagine: 23 - 35
SICI:
1386-1964(20010901)480:<23:AAAFTP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; OXIDATIVE DNA-DAMAGE; FRIED GROUND-BEEF; COLON-CANCER; GREEN TEA; BLACK TEA; LIVER CARCINOGENESIS; COLORECTAL-CANCER; TRANSGENIC MOUSE; TUMOR PROMOTION;
Keywords:
antimutagenesis; anticarcinogenesis; Salmonella typhimurium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Weisburger, JH Amer Hlth Fdn, 1 Dana Rd, Valhalla, NY 10595 USA Amer Hlth Fdn 1 Dana Rd Valhalla NY USA 10595 NY 10595 USA
Citazione:
J.H. Weisburger, "Antimutagenesis and anticarcinogenesis, from the past to the future", MUT RES-F M, 480, 2001, pp. 23-35

Abstract

Observations on cancer causation are some 150 years old, but actual detailed research on elements bearing on cancer started at the beginning of the twentieth century. Rapid progress, however, is only some 40 years old, Studies in humans documented certain lifestyle related factors to lead to cancer, and research in animal models strengthened this information. With the realization that there are carcinogens that in a metabolically activated attack DNA, in contrast to other agents that act by promoting, enhancing processes through totally distinct mechanisms, it became possible to develop and apply tests for DNA reactivity, in a prokaryotic organism, the widely used Salmonella typhimurium test by Ames and in a eukaryotic system, namely freshly explanted liver cells displaying evidence of DNA repair by Williams. A battery of these two tests are over 90% accurate in defining genotoxicity. Virtually all documented human carcinogens are genotoxic. With advances in molecular biology, mutational events are traced to changes in tumor suppressor genes or in oncogenes, that can serve as markers of risk. In addition, reactive oxygen systems (ROS) are involved in both the early steps in cancerand in the developmental aspects. Thus, foods containing antioxidants suchas vegetables, fruits, soy products, cocoa and tea that counteract ROS areprotective in cancer causation and development. Worldwide application of current knowledge and mechanisms to cancer prevention, the definitive means of cancer control, is likely to lower not only cancer but also heart disease risk in the current century. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:41:02