Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects
Autore:
Alonso-Monge, R; Real, E; Wojda, I; Bebelman, JP; Mager, WH; Siderius, M;
Indirizzi:
Vrije Univ Amsterdam, Bioctr Amsterdam, IMBW, Dept Biochem & Mol Biol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam NetherlandsNL-1081 HV erdam, Netherlands Marie Curie Sklodowska Univ, Inst Biol, PL-20033 Lublin, Poland Marie Curie Sklodowska Univ Lublin Poland PL-20033 -20033 Lublin, Poland
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 3, volume: 41, anno: 2001,
pagine: 717 - 730
SICI:
0950-382X(200108)41:3<717:HSRARO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; SIGNAL-TRANSDUCTION PATHWAY; OSMOTIC-STRESS; MAP KINASE; HOG PATHWAY; SHO1-DEPENDENT ACTIVATION; TYROSINE PHOSPHATASES; GLUCANASE RESISTANCE; ELEMENT STRE; YEAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Siderius, M Vrije Univ Amsterdam, Bioctr Amsterdam, IMBW, Dept Biochem & Mol Biol, De Boelelaan 1083, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam De Boelelaan 1083 Amsterdam Netherlands NL-1081 HV
Citazione:
R. Alonso-Monge et al., "Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects", MOL MICROB, 41(3), 2001, pp. 717-730

Abstract

The osmosensitive phenotype of the hog1 strain is suppressed at elevated temperature. Here, we show that the same holds true for the other commonly used HOG pathway mutant strains pbs2 and sho1ssk2ssk22, but not for ste11ssk2ssk22. Instead, the ste11ssk2ssk2 strain displayed a hyperosmosensitive phenotype at 37 degreesC. This phenotype is suppressed by overexpression of LRE1, HLR1 and WSC3, all genes known to influence cell wall composition. Thesuppression of the temperature-induced hyperosmosensitivity by these genesprompted us to investigate the role of STE11 and other HOG pathway components in cellular integrity and, indeed, we were able show that HOG pathway mutants display sensitivity to cell wall-degrading enzymes. LRE1 and HLR1 were also shown to suppress the cell wall phenotypes associated with the HOG pathway mutants. In addition, the isolated multicopy suppressor genes suppress temperature-induced cell lysis phenotypes of PKC pathway mutants that could be an indication for shared targets of the PKC pathway and high-osmolarity response routes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:41:49