Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Valproate induces in vitro accumulation of long-chain fatty acylcarnitines
Autore:
Silva, MFB; Jakobs, C; Duran, M; de Almeida, IT; Wanders, RJA;
Indirizzi:
Univ Lisbon, Fac Farm, Ctr Patogenese Mol, P-1649003 Lisbon, Portugal UnivLisbon Lisbon Portugal P-1649003 se Mol, P-1649003 Lisbon, Portugal Univ Amsterdam, Acad Med Ctr, Dept Clin Chem & Paediat, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Free Univ Amsterdam Hosp, Dept Clin Chem, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands
Titolo Testata:
MOLECULAR GENETICS AND METABOLISM
fascicolo: 4, volume: 73, anno: 2001,
pagine: 358 - 361
SICI:
1096-7192(200108)73:4<358:VIIVAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSSIBLE CLINICAL-SIGNIFICANCE; COENZYME-A; CARNITINE SUPPLEMENTATION; ACID THERAPY; HEPATOTOXICITY; METABOLISM; EPILEPSY; PLASMA; MICE;
Keywords:
valproic acid; acylcarnitine; carnitine; fatty acid beta-oxidation; long-chain fatty acids; long-chain acylcarnitines; valproate metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: de Almeida, IT Univ Lisbon, Fac Farm, Ctr Patogenese Mol, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal Univ Lisbon Av Prof Gama Pinto Lisbon Portugal P-1649003 l
Citazione:
M.F.B. Silva et al., "Valproate induces in vitro accumulation of long-chain fatty acylcarnitines", MOL GEN MET, 73(4), 2001, pp. 358-361

Abstract

To elucidate the interference mechanisms of valproate (VPA) with mitochondrial fatty acid beta -oxidation (FAO), the profile of acylcarnitine formation was studied in vitro. Human fibroblasts were incubated with 0.2 mmol/L [U-C-13]palmitate, 0.4 mmol/L L-carnitine, +/- VPA (2 mmol/L) (96 h at 37 degreesC). Acylcarnitines (AC) were analyzed by GC-CI-MS. VPA induced an impaired production of acetylcarnitine (C2) and an increase on long-chain AC (C10 to C16) both in control and in FAO-deficient cell lines (VLCAD, LCHAD, MTP). (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:40:36