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Titolo:
Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: Studies from intraocular grafts
Autore:
Granholm, AC; Helt, C; Srivastava, N; Backman, C; Gerhardt, GA;
Indirizzi:
Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA Univ Rochester, Toxicol Grad Program, Rochester, NY USA Univ Rochester Rochester NY USA Toxicol Grad Program, Rochester, NY USA Univ Minnesota, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 nesota, Minneapolis, MN 55455 USA NIDA, Intramural Res Program, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 tramural Res Program, Baltimore, MD 21224 USA Univ Kentucky, Dept Anat, Lexington, KY 40536 USA Univ Kentucky LexingtonKY USA 40536 , Dept Anat, Lexington, KY 40536 USA Univ Kentucky, Dept Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 t Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Dept Neurol, Lexington, KY 40536 USA
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 5, volume: 54, anno: 2001,
pagine: 298 - 308
SICI:
1059-910X(20010901)54:5<298:EOAAGO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS IN-VIVO; LOCUS-COERULEUS; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; MESSENGER-RNA; RAT-BRAIN; PARKINSONS-DISEASE; NERVOUS SYSTEMS; NOREPINEPHRINE;
Keywords:
noradrenergic neurons; locus coeruleus; glial cell line-derived neurotrophic factor; hippocampal formation; iris; aging; neuroplasticity; sprouting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Granholm, AC Med Univ S Carolina, Dept Physiol & Neurosci, 173 Ashley St, Charleston, SC 29425 USA Med Univ S Carolina 173 Ashley St Charleston SC USA 29425 USA
Citazione:
A.C. Granholm et al., "Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: Studies from intraocular grafts", MICROSC RES, 54(5), 2001, pp. 298-308

Abstract

Recent studies have suggested that factors in the target tissue influence the degree of plasticity and regeneration following aging and/or specific insults. We have investigated whether young or aged targets differ in their noradrenergic innervation from fetal locus coeruleus (LC) neurons, and alsoif a specific growth factor, glial cell line-derived neurotrophic factor (GDNF) can affect this innervation pattern. Tissue pieces of fetal brainstemand young (3 months) or old (18 months) iris tissue were transplanted simultaneously into the anterior chamber of the eye of adult hosts. We found that aged iris transplants became innervated to a significantly lesser degreeby the cografted LC neurons than young iris transplants. Fetal hippocampaltissue was then grafted to adult hosts, and a fetal brainstem graft containing LC neurons was placed adjacent to the first graft, either at 3 or 21 months post-grafting. Thus, old/young chimeras of the noradrenergic coeruleo-hippocampal pathway were created. Aged hippocampal grafts received a much less dense innervation from co-grafted LC neurons than young hippocampal grafts. Tyrosine hydroxylase-positive-immunoreactive innervation was only found in the outskirts of aged grafts, while the young hippocampal grafts contained an even innervation pattern. The innervation density of hippocampal grafts was significantly enhanced by GDNF treatment. These findings demonstrate that target-derived factors may regulate neuronal plasticity, and that the age of the target is more important for innervation properties than theage of the neuron innervating a particular target. Microsc. Res. Tech. 54:298-308, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 10/04/20 alle ore 15:54:38