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Titolo:
A genomic sequence analysis of the mouse and human microtubule-associated protein tau
Autore:
Poorkaj, P; Kas, A; DSouza, I; Zhou, Y; Pham, Q; Stone, M; Olson, MV; Schellenberg, GD;
Indirizzi:
Vet Affairs Puget Sound Hlth Care Syst, GRECC 182B, Seattle Div, Seattle, WA 98108 USA Vet Affairs Puget Sound Hlth Care Syst Seattle WA USA 98108 WA 98108 USA Univ Washington, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 & Geriatr Med, Seattle, WA 98195 USA Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Genet, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 n, Dept Genet, Seattle, WA 98195 USA Univ Washington, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 9, volume: 12, anno: 2001,
pagine: 700 - 712
SICI:
0938-8990(200109)12:9<700:AGSAOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; MOLECULAR-WEIGHT TAU; INHERITED DEMENTIA FTDP-17; CENTRAL-NERVOUS-SYSTEM; LOCUS-CONTROL REGIONS; MESSENGER-RNA; ALZHEIMERS-DISEASE; FRONTOTEMPORAL DEMENTIA; ANTISENSE OLIGONUCLEOTIDES; CORTICOBASAL DEGENERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Schellenberg, GD Vet Affairs Puget Sound Hlth Care Syst, GRECC 182B, Seattle Div, 1660 S Columbian Way, Seattle, WA 98108 USA Vet Affairs Puget SoundHlth Care Syst 1660 S Columbian Way Seattle WA USA 98108
Citazione:
P. Poorkaj et al., "A genomic sequence analysis of the mouse and human microtubule-associated protein tau", MAMM GENOME, 12(9), 2001, pp. 700-712

Abstract

Microtubule associated protein tau (MAPT) encodes the microtubule associated protein tau, the primary component of neurofibrillary tangles found in Alzheimer's disease and other neurodegenerative disorders. Mutations in the coding and intronic sequences of MAPT cause autosomal dominant frontotemporal dementia (FTDP-17). MAPT is also a candidate gene for progressive supranuclear palsy and hereditary dysphagic dementia. A human PAC (201 kb) and a mouse BAC (161 kb) containing the entire MAPT and Mtapt genes, respectively, were identified and sequenced. Comparative DNA sequence analysis revealedover 100 conserved non-repeat potential cis-acting regulatory sequences inor close to MAPT. Those islands with greater than 67% nucleotide identity range in size from 20 to greater than 1700 nucleotides. Over 90 single nucleotide, polymorphisms were identified in MAPT that are candidate susceptibility alleles for neurodegenerative disease. The 5' and 3' flanking genes for MAPT are the corticotrophin-releasing factor receptor (CRFR) gene and KIAA1267, a gene of unknown function expressed in brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:11:37