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Titolo:
Gd-DTPA bolus tracking in the myocardium using T-1 fast acquisition relaxation mapping (T-1 FARM)
Autore:
Bellamy, DD; Pereira, RS; McKenzie, CA; Prato, FS; Drost, DJ; Sykes, J; Wisenberg, G;
Indirizzi:
Univ Western Ontario, Lawson Hlth Res Inst, Dept Nucl Med & Magnet Resonance, Div Cardiol, London, ON N6A 4V2, Canada Univ Western Ontario London ONCanada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, Dept Med Biophys, St Josephs Hlth Ctr, London, ON, Canada Univ Western Ontario London ON Canada sephs Hlth Ctr, London, ON, Canada Foothills Prov Gen Hosp, Seaman Family MR Res Ctr, Calgary, AB T2N 2T9, Canada Foothills Prov Gen Hosp Calgary AB Canada T2N 2T9 ary, AB T2N 2T9, Canada Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 d, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 46, anno: 2001,
pagine: 555 - 564
SICI:
0740-3194(200109)46:3<555:GBTITM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSION RESERVE; CONTRAST AGENTS; FIRST-PASS; EXTRACTION EFFICIENCY; BREATH-HOLD; BLOOD-FLOW; VIABILITY; QUANTIFICATION; MODEL; MRI;
Keywords:
cardiac MRI; Gd-DTPA; myocardial perfusion reserve; T-1-mapping; T-1 FARM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Prato, FS Univ Western Ontario, St Josephs Hlth Ctr, Dept Nucl Med & Magnet Resonance, 268 Grosvenor St, London, ON N6A 4V2, Canada Univ Western Ontario 268 Grosvenor St London ON Canada N6A 4V2 a
Citazione:
D.D. Bellamy et al., "Gd-DTPA bolus tracking in the myocardium using T-1 fast acquisition relaxation mapping (T-1 FARM)", MAGN RES M, 46(3), 2001, pp. 555-564

Abstract

MRI methods currently used for bolus tracking in the myocardium, such as saturation recovery turbo-fast low-angle shot (FLASH) (srTFL), are limited by signal intensity (SI) saturation at high contrast agent (CA) concentrations. By using T-1 fast acquisition relaxation mapping (T-1 FARM), a Gd-DTPA bolus (0.075 vs. 0.025 mmol/kg) may be injected without causing saturation. This study tested the feasibility of in vivo T-1 FARM bolus tracking underrest/stress conditions in seven beagles with multiple permanently occludedbranches of the left anterior descending (LAD) coronary artery. Although it underestimated the myocardial perfusion reserve (MPR) measured ex vivo using radioactive microspheres (mean SEM; 3.60 +/- 0.26), the MPR determined upon application of the modified Kety model (1.86 +/- 0.10) enabled distinction between normal and infarcted tissue. The partition coefficient (lambda) estimated at rest and stress using the modified Kety model underestimatedex vivo radioactive measurements in infarcted tissue (0.25 +/- 0.01 vs. 0.26 +/- 0.01 vs. 0.79 +/- 0.08 ml/g, P < 0.0001) yet was accurate in normal tissue (0.28 +/- 0.01 vs. 0.30 +/- 0.01 vs. 0.33 +/- 0.01 ml/g, P = NS). Thus, although unsuitable far myocardial viability assessment, Ti FARM bolus tracking shows potential for assessment of myocardial perfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:32:02