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Titolo:
MR perfusion imaging using encapsulated laser-polarized He-3
Autore:
Callot, V; Canet, E; Brochot, J; Viallon, M; Humblot, H; Briguet, A; Tournier, H; Cremillieux, Y;
Indirizzi:
Univ Lyon 1, Lab Resonance Magnet Nucl, CNRS, UMR 5012,CPE, F-69616 Villeurbanne, France Univ Lyon 1 Villeurbanne France F-69616 PE, F-69616 Villeurbanne, France Hop Cardio Vasc Louis Pradel, CNR, UMR 5515, Lyon, France Hop Cardio Vasc Louis Pradel Lyon France l, CNR, UMR 5515, Lyon, France Bracco Res, Geneva, Switzerland Bracco Res Geneva SwitzerlandBracco Res, Geneva, Switzerland Inst Max Von Laue Paul Langevin, F-38042 Grenoble, France Inst Max Von Laue Paul Langevin Grenoble France F-38042 Grenoble, France
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 46, anno: 2001,
pagine: 535 - 540
SICI:
0740-3194(200109)46:3<535:MPIUEL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERPOLARIZED XE-129; IN-VIVO; CONTRAST AGENT; GAS; MICROBUBBLES; VENTILATION; DYNAMICS; NMR;
Keywords:
hyperpolarized helium; microbubbles; blood tracer; lung perfusion imaging; rat lung;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Cremillieux, Y Univ Lyon 1, Lab Resonance Magnet Nucl, CNRS, UMR 5012,CPE,Domaine Sci Doua,3 Rue Victor Grignard,Alle C, F-69616 Villeurbanne, France Univ Lyon 1 Domaine Sci Doua,3 Rue Victor Grignard,Alle C Villeurbanne France F-69616
Citazione:
V. Callot et al., "MR perfusion imaging using encapsulated laser-polarized He-3", MAGN RES M, 46(3), 2001, pp. 535-540

Abstract

In this work, the use of a new carrier agent for intravascular laser-polarized He-3 imaging is reported. Lipid-based helium microbubbles were investigated. Their average diameter of 3 mum, which is smaller than that of the capillaries, makes it possible to conduct in vivo studies. The NMR relaxation parameters T-1, T-2, and T-2* of a microbubble suspension were measured as 90 s, 300 ms, and 4.5 ms, respectively, and in vivo images of encapsulated He-3 with signal-to-noise ratios (SNRs) larger than 30 were acquired. Dynamic cardiac images and vascular images of encapsulated He-3 were obtained in rats using intravenous injections of microbubble suspensions. Excellent preservation of He-3 polarization through the lung capillaries and heart cavities was observed. The first images of He-3 microbubble distributions in the lungs were obtained. Additionally, the potential of this technique for lung perfusion assessment was validated through an experimental embolism model with the visualization of perfusion defects. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:50:40