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Titolo:
T-2 relaxation reveals spatial collagen architecture in articular cartilage: A comparative quantitative MRI and polarized light microscopic study
Autore:
Nieminen, MT; Rieppo, J; Toyras, J; Hakumaki, JM; Silvennoinen, J; Hyttinen, MM; Helminen, HJ; Jurvelin, JS;
Indirizzi:
Univ Kuopio, Dept Anat, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 ept Anat, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 l Med, SF-70210 Kuopio, Finland Univ Kuopio, Natl BioNMR Facil, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Mol Sci, FIN-70211 Kuopio, Finland
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 46, anno: 2001,
pagine: 487 - 493
SICI:
0740-3194(200109)46:3<487:TRRSCA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE MICROSCOPY; SPECIMEN PREPARATION; HYALINE CARTILAGE; SIGNAL INTENSITY; NMR MICROSCOPY; SAFRANIN-O; GLYCOSAMINOGLYCANS; BIREFRINGENCE; SECTIONS; VISUALIZATION;
Keywords:
MRI; T-2; articular cartilage; polarized light microscopy; collagen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nieminen, MT Univ Kuopio, Dept Anat, POB 1627, FIN-70211 Kuopio, Finland Univ Kuopio POB 1627 Kuopio Finland FIN-70211 uopio, Finland
Citazione:
M.T. Nieminen et al., "T-2 relaxation reveals spatial collagen architecture in articular cartilage: A comparative quantitative MRI and polarized light microscopic study", MAGN RES M, 46(3), 2001, pp. 487-493

Abstract

It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise T-2 anisotropy of MRI through the magic angle effect. To investigate the relationship between laminar T-2 appearance and collagen organization (anisotropy), bovine osteochondralplugs (N = 9) were T-2 mapped at 9.4T with cartilage surface normal to thestatic magnetic field. Collagen fibril arrangement of the same samples wasstudied with polarized light microscopy, a quantitative technique for probing collagen organization by analyzing its ability to rotate plane polarized light, i.e., birefringence (BF). Depthwise variation of safranin O-stained proteoglycans was monitored with digital densitometry, The spatially varying cartilage T-2 followed the architectural arrangement of the collagen fibril network: a linear positive correlation between T-2 and the reciprocal of BF was established in each sample, with r = 0.91 +/- 0.02 (mean SEM, N =9). The current results reveal the close connection between the laminar T-2 structure and the collagen architecture in histologic zones. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:13:57