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Titolo:
BCR-ABL fusion peptides and cytotoxic T cells in chronic myeloid leukaemia
Autore:
Clark, RE; Christmas, SE;
Indirizzi:
Univ Liverpool, Dept Haematol, Liverpool L7 8XP, Merseyside, England Univ Liverpool Liverpool Merseyside England L7 8XP P, Merseyside, England Univ Liverpool, Dept Immunol, Liverpool L7 8XP, Merseyside, England Univ Liverpool Liverpool Merseyside England L7 8XP P, Merseyside, England
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5, volume: 42, anno: 2001,
pagine: 871 - 880
SICI:
1042-8194(200109/10)42:5<871:BFPACT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; CLASS-I MOLECULES; PHILADELPHIA-CHROMOSOME; DENDRITIC CELLS; SPONTANEOUS REMISSION; JOINING REGION; NORMAL DONORS; CHRONIC PHASE; IMMUNE-RESPONSES; B3A2 PEPTIDE;
Keywords:
CML; BCR-ABL; HLA; peptides; cytotoxic T lymphocytes; helper T lymphocytes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, RE Univ Liverpool, Dept Haematol, Prescot St, Liverpool L7 8XP, Merseyside, England Univ Liverpool Prescot St Liverpool Merseyside England L7 8XP nd
Citazione:
R.E. Clark e S.E. Christmas, "BCR-ABL fusion peptides and cytotoxic T cells in chronic myeloid leukaemia", LEUK LYMPH, 42(5), 2001, pp. 871-880

Abstract

The BCR-ABL gene that arises in chronic myeloid leukaemia (CML) is a neoantigen. Peptides derived from the BCR-ABL fusion junction may therefore be immunogenic, if appropriately presented to the immune system. This article reviews data demonstrating that certain junctional peptides will bind to HLAmolecules, and that these peptides will elicit specific T-lymphocyte responses in vitro, in both normal subjects and in CML patients. The clinical relevance of these observations is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:18:38