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Titolo:
Angiogenesis in acute and chronic leukemias
Autore:
Dickson, DJ; Shami, PJ;
Indirizzi:
SLC VA Med Ctr, Salt Lake City, UT 84148 USA SLC VA Med Ctr Salt Lake City UT USA 84148 , Salt Lake City, UT 84148 USA Univ Utah, Dept Med, Div Med Oncol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Oncol, Salt Lake City, UT 84112 USA
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5, volume: 42, anno: 2001,
pagine: 847 -
SICI:
1042-8194(200109/10)42:5<847:AIAACL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; TUMOR ANGIOGENESIS; BONE-MARROW; PROGNOSTIC INDICATOR; CANCER; EXPRESSION; CARCINOMA; CELLS;
Keywords:
angiogenesis; leukemia; VEGF; bFGF;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shami, PJ SLC VA Med Ctr, Box 151M,500 Foothill Blvd, Salt Lake City, UT 84148 USA SLC VA Med Ctr Box 151M,500 Foothill Blvd Salt Lake City UT USA 84148
Citazione:
D.J. Dickson e P.J. Shami, "Angiogenesis in acute and chronic leukemias", LEUK LYMPH, 42(5), 2001, pp. 847

Abstract

Angiogenesis plays a key role in the growth of solid tumors. More recently, accumulating evidence has linked angiogenesis to the pathophysiology of leukemias. Different investigators have shown evidence of increased angiogenesis in the bone marrows of patients with acute and chronic leukemias. Elevated levels of angiogenic factors have also been reported in leukemic patients. A potential role for VEGF as an autocrine growth factor in AML has been suggested. Studies on the role of angiogenesis and VEGF as prognostic factors in leukemia require confirmation. The role of angiogenesis inhibitors in the treatment of leukemia is currently under investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:03:47