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Titolo:
CD95 antigen mutations in hematopoietic malignancies
Autore:
Landowski, TH; Moscinski, L; Burke, R; Buyuksal, I; Painter, JS; Goldstein, S; Dalton, WS;
Indirizzi:
Univ S Florida, H Lee Moffitt Canc Ctr, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 disciplinary Oncol, Tampa, FL 33612 USA Univ S Florida, H Lee Moffitt Canc Ctr, Dept Pathol, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 c Ctr, Dept Pathol, Tampa, FL 33612 USA Univ S Florida, H Lee Moffitt Canc Ctr, Clin Invest Program, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 lin Invest Program, Tampa, FL 33612 USA Univ S Florida, Res Inst, Tampa, FL 33612 USA Univ S Florida Tampa FL USA33612 Florida, Res Inst, Tampa, FL 33612 USA
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5, volume: 42, anno: 2001,
pagine: 835 -
SICI:
1042-8194(200109/10)42:5<835:CAMIHM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAS-MEDIATED APOPTOSIS; NON-HODGKINS-LYMPHOMA; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; MESSENGER-RNA EXPRESSION; B-CELLS; LIGAND EXPRESSION; MULTIPLE-MYELOMA; LEUKEMIA-CELLS; FAS/APO-1 GENE; WILD-TYPE;
Keywords:
CD95 mutations; hematopoietic malignancy; Fas/APO-I; TNF-R; B-cell lymphomas;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Landowski, TH Univ S Florida, H Lee Moffitt Canc Ctr, Dept Interdisciplinary Oncol, 12902 Magnolia Dr, Tampa, FL 33612 USA Univ S Florida 12902 Magnolia Dr Tampa FL USA 33612 3612 USA
Citazione:
T.H. Landowski et al., "CD95 antigen mutations in hematopoietic malignancies", LEUK LYMPH, 42(5), 2001, pp. 835

Abstract

The CD95 receptor, also known as Fas/Apo-1, is a member of the Tumor Necrosis Factor receptor (TNF-R) family of death receptors. Apoptosis mediated by CD95 plays a central role in maintaining homeostasis of the immune system. Dysregulation of the CD95 apoptotic pathway has been proposed as a mechanism of oncogenesis by providing a survival advantage to potentially malignant cells. This extended lifespan could allow the accumulation of further mutations leading to malignant transformation. Several mechanisms of resistance to CD95 mediated apoptosis have been identified, including reduced surface expression of the receptor, overexpression of anti-apoptotic molecules, and loss of function mutations. This review will focus on the potential role of the CD95-CD95 Ligand system in the pathogenesis of hematological malignancies, with particular emphasis on recent work from our laboratory examining the expression of CD95 in B cell lymphomas. We demonstrate that CD95 mutations occur at low frequency in NHL turnors, however, surface expression of the CD95 protein varies with the subtype of lymphoma. Loss of surface CD95 is more likely to occur in lymphomas of aggressive histology, and is unrelated to the detection of CD95 mutations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:22:54