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Titolo:
Identification of genes expressed in the amygdala during the formation of fear memory
Autore:
Stork, O; Stork, S; Pape, HC; Obata, K;
Indirizzi:
Natl Inst Physiol Sci, Neurochem Lab, Okazaki, Aichi 4448585, Japan Natl Inst Physiol Sci Okazaki Aichi Japan 4448585 i, Aichi 4448585, Japan Univ Magdeburg, Sch Med, Inst Physiol, D-39120 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39120 iol, D-39120 Magdeburg, Germany
Titolo Testata:
LEARNING & MEMORY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 209 - 219
SICI:
1072-0502(200107/08)8:4<209:IOGEIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ADHESION MOLECULE NCAM; PROTEIN-SYNTHESIS; CONDITIONED FEAR; LATERAL AMYGDALA; BINDING PROTEIN; RING-H2 MOTIF; RAT AMYGDALA; C-FOS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Stork, O Natl Inst Physiol Sci, Neurochem Lab, Okazaki, Aichi 4448585, Japan Natl Inst Physiol Sci Okazaki Aichi Japan 4448585 4448585, Japan
Citazione:
O. Stork et al., "Identification of genes expressed in the amygdala during the formation of fear memory", LEARN MEM, 8(4), 2001, pp. 209-219

Abstract

In this study we describe changes of gene expression that occur in the basolateral complex of the mouse amygdala (BLA) during the formation of fear memory. Through the combination of a behavioral training scheme with polymerase chain reaction-based expression analysis (subtractive hybridization andvirtual Northern analysis) we were able to identify various gene products that are increased in expression after Pavlovian fear conditioning and are of potential significance for neural plasticity and information storage in the amygdala. In particular, a key enzyme of monoamine metabolism, aldehydereductase, and the protein sorting and ubiquitination factor Praja1, showed pronounced and learning-specific induction six hours after fear conditioning training. Aldehyde reductase and Praja1, including a novel alternatively spliced isoform termed Praja1a, were induced in the BLA depending on the emotional stimulus presented and showed different expression levels in response to associative conditioning, training stress, and experience of conditioned fear. Stress and fear were further found to induce various signal transduction factors (transthyretin, phosphodiesterase1, protein kinase inhibitor-alpha) and structural reorganization factors (e.g., E2-ubiquitin conjugating enzyme, neuroligin1, actin, UDP-galactose transporter) during training. Our results show that the formation of Pavlovian fear memory is associated with changes of gene expression in the BLA, which may contribute to neural plasticity and the processing of information about both conditioned and unconditioned fear stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:27:41