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Titolo:
Influence of ETB receptor antagonism on pregnancy outcome in rats
Autore:
Madsen, KM; Neerhof, MG; Wessale, JL; Thaete, LG;
Indirizzi:
Northwestern Univ, Sch Med, Evanston NW Healthcare, Dept Obstet & Gynecol,Div Maternal Fetal Med, Evanston, IL 60201 USA Northwestern Univ Evanston IL USA 60201 Fetal Med, Evanston, IL 60201 USA Abbott Labs, Pharmaceut Discovery, Abbott Pk, IL 60064 USA Abbott Labs Abbott Pk IL USA 60064 eut Discovery, Abbott Pk, IL 60064 USA
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 4, volume: 8, anno: 2001,
pagine: 239 - 244
SICI:
1071-5576(200107/08)8:4<239:IOERAO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ENDOTHELIN RECEPTORS; CHRONIC BLOCKADE; BLOOD-PRESSURE; IN-VITRO; HYPERTENSION; INHIBITION; RESTRICTION; PEPTIDES;
Keywords:
intrauterine growth restriction; endothelin receptor antagonism; rat; hypertension; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Thaete, LG Northwestern Univ, Sch Med, Evanston NW Healthcare, Dept Obstet& Gynecol,Div Maternal Fetal Med, 2650 Ridge Ave,Suite 1600 WH, Evanston, IL 60201 USA Northwestern Univ 2650 Ridge Ave,Suite 1600 WH Evanston IL USA60201
Citazione:
K.M. Madsen et al., "Influence of ETB receptor antagonism on pregnancy outcome in rats", J SOC GYN I, 8(4), 2001, pp. 239-244

Abstract

Objective: To determine the effect of endothelin-B (ETB)-selective receptor antagonism on pregnancy outcome in normal rats. Methods: ETB receptor antagonist (A-192621; 5.0, 10.0, and 15.0 mg/kg per day) or vehicle was infused subcutaneously for 7 days by osmotic pump. Infusion was begun on day 14 of a 22-day gestation. Nonpregnant animals were treated similarly, and blood pressure (BP) responses and plasma antagonist levels were compared to those in pregnant animals. Mean arterial pressure (MAP) was measure on days 1,4, and 7 of the infusion. Plasma ETB antagonist levels were measured on day 7 of infusion. On gestational day 21, fetal and placental weights and viability were evaluated at hysterotomy. Data were analyzed by analysis of variance and are presented as mean +/- standard error of the mean. Results: Fetal and placental weights were significantly lower at doses of 10 and 15 mg/kg per day of the ETB antagonist compared with vehicle-treatedcontrols (P<.001); these effects were less severe at 15 than at 10 mg/kg per day despite a four-fold higher plasma level of antagonist. Mean arterialpressure was significantly higher at 10 and 15 mg/kg per day compare with controls, but only on infusion day 1 (P<.05). In contrast, MAPs for nonpregnant rats were elevated throughout the infusion at all doses of the ETB antagonist (P<.05). Conclusions: ETB receptor antagonism inhibited fetal growth and increased maternal MAP in a dose-dependent manner although the effect on BP was not sustained in pregnant animals. ETB receptor antagonism is detrimental to pregnancy outcome in the rat. (J Soc Gynecol Investig 2001; 8:239-44) Copyright (C) 2001 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:36:27