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Titolo:
Salmon GnRH and its analogues bind the human placental receptor
Autore:
Siler-Khodr, TM; Grayson, M;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Obstet & Gynecol, San Antonio, TX 78284 USAUniv Texas San Antonio TX USA 78284 & Gynecol, San Antonio, TX 78284 USA
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 4, volume: 8, anno: 2001,
pagine: 233 - 238
SICI:
1071-5576(200107/08)8:4<233:SGAIAB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; HUMAN CHORIONIC-GONADOTROPIN; HUMAN TERM PLACENTA; INACTIVATES GNRH; GENE-EXPRESSION; CELLS; PROGESTERONE; SECRETION; GESTATION; LHRH;
Keywords:
placenta; receptor; salmon GnRH; mammalian GnRH; lamprey I GnRH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Siler-Khodr, TM Univ Texas, Hlth Sci Ctr, Dept Obstet & Gynecol, 7703 Floyd Curl Dr,Room 416E, San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr,Room 416E San Antonio TX USA 78284
Citazione:
T.M. Siler-Khodr e M. Grayson, "Salmon GnRH and its analogues bind the human placental receptor", J SOC GYN I, 8(4), 2001, pp. 233-238

Abstract

Objective: The presence of GnRH receptors in the human placenta has been recognized for a number of years. However, mammalian GnRH, which is expressed in placental tissues, has limited affinity for the chorionic receptor. Onthe basis of immunological and bioactivity data, we have previously proposed that the chorionic GnRH may differ from mammalian GnRH. Methods: we have studied the affinity of another isoform of GnRH (ie, salmon GnRH and stable analogues of this GnRH isoform), and compared their receptor affinity to that of mammalian GnRH and it analogues. Results: Using our receptor assay method with the labeled mammalian GnRH analogue Buserelin, salmon GnRH had a twofold greater affinity for the placental GnRH receptor than did mammalian GnRH and for the stable salmon GnRH analogue the affinity was increased tenfold. Using a homologous receptor assay method with a stable salmon GnRH analogue as label, the affinity for this salmon Gn RH analogue had a K-d of 101 nmol/L. Conclusion: The presence of these higher affinity receptors for non mammalian GnRH in the human placenta has led us to propose that the chorionic tissues may express more than on iso form of GnRH and that non-mammalian GnRH,such as salmon GnRH, may be potent regulators of placental functions. (J Soc Gynecol Investig 2001; 8:233-8) Copyright (C) 2001 by the Society of Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 00:07:50