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Titolo:
Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells
Autore:
Kametani, F; Tanaka, K; Usami, M; Maruyama, K; Mori, H;
Indirizzi:
Tokyo Inst Psychiat, Dept Mol Biol, Setagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 etagaya Ku, Tokyo 1568585, Japan Osaka City Univ, Sch Med, Dept Neurosci, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Dept Neurosci, Osaka 5458585, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 188, anno: 2001,
pagine: 27 - 31
SICI:
0022-510X(20010715)188:1-2<27:HWPMTE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-SECRETASE ACTIVITY; BETA-PROTEIN; TRANSFECTED CELLS; TRANSGENIC MICE; IN-VIVO; DISEASE; MUTATIONS; EXPRESSION; CLEAVAGE; BRAINS;
Keywords:
Alzheimer; amyloid; A beta, presenilin-1; PC12D; gamma-secretase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kametani, F Tokyo Inst Psychiat, Dept Mol Biol, Setagaya Ku, 2-1-8 Kamikitazawa, Tokyo1568585, Japan Tokyo Inst Psychiat 2-1-8 Kamikitazawa Tokyo Japan 1568585 an
Citazione:
F. Kametani et al., "Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells", J NEUR SCI, 188(1-2), 2001, pp. 27-31

Abstract

Most familial early-onset Alzheimer's disease (FAD) is caused by mutationsin the presenilin-I (PSI) gene. A beta 42 is derived from amyloid precursor protein (APP) and increased concentrations are widely believed to be a pathological hallmark of abnormal PS function. Thus, the interaction between PS1 and APP is central to the molecular mechanism of AD. To examine the effect of wild-type human PS1 on rat APP metabolism. we made several PC12D cell lines that expressed human wild or mutant PS1, and analyzed the processing of endogenous rat APP and the intracellular gamma -secretase activity. Wefound the ratio of A beta 42/A beta 40 increased in PC12D cells expressingwild-type human PS1. These changes were identical to those found in PC12D cells expressing human PS1 bearing the A260V mutation. These results suggest that APP metabolism is physiologically regulated by the PS1 and that lossof normal PS1 affects gamma -secretase activity. (C) 2001 Elsevier ScienceB.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:17:52