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Titolo:
Novel nitric oxide donor (FK409) ameliorates liver damage during extended liver resection with warm ischemia in dogs
Autore:
Aiba, M; Takeyoshi, I; Ohwada, S; Kawashima, Y; Iwanami, K; Sunose, Y; Yamada, T; Tsutsumi, H; Matsumoto, K; Morishita, Y;
Indirizzi:
Gunma Univ, Sch Med, Dept Surg 2, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 2, Maebashi, Gumma 3718511, Japan Nippon Med Coll, Dept Pathol, Kawasaki, Kanagawa, Japan Nippon Med Coll Kawasaki Kanagawa Japan athol, Kawasaki, Kanagawa, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
fascicolo: 3, volume: 193, anno: 2001,
pagine: 264 - 271
SICI:
1072-7515(200109)193:3<264:NNOD(A>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER; REPERFUSION INJURY; L-ARGININE; ENDOTHELIN-1; VASODILATOR; RELEASE; CELLS; ISCHEMIA/REPERFUSION; INHIBITION; VASOCONSTRICTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Takeyoshi, I Gunma Univ, Sch Med, Dept Surg 2, 3-39-15 Showa Machi, Maebashi, Gumma 3718511, Japan Gunma Univ 3-39-15 Showa Machi Maebashi Gumma Japan 3718511 n
Citazione:
M. Aiba et al., "Novel nitric oxide donor (FK409) ameliorates liver damage during extended liver resection with warm ischemia in dogs", J AM COLL S, 193(3), 2001, pp. 264-271

Abstract

BACKGROUND: Nitric oxide attenuates ischemia-reperfusion injury by maintaining organ circulation through its actions as a vasoregulator, an inhibitorof platelet aggregation, and an attenuator of leukocyte adhesion. Otherwise, the harmful effects of enhanced nitric oxide production induced by inducible nitric oxide synthase mediate ischemia-reperfusion injury. FK409 has been characterized as a spontaneous nitric oxide donor. The aim of this study was to evaluate the effects of FK409 on extended liver resection with ischemia using a canine model. STUDY DESIGN: Adult mongrel dogs were subjected to 60 minutes of warm ischemia by partial inflow occlusion. After reperfusion the nonischemic lobes were resected and the remnant liver function was evaluated. The dogs were divided into two groups: the control group (n = 7) and the FK409 group (n = 6), which was given FK409 through the portal vein. RESULTS: The hepatic tissue blood flow, serum liver enzymes levels, and serum endothelin-1 level after reperfusion were significantly better in the FK409 group than in the control group. Electron microscopy demonstrated thatendothelial cells and Ito cells were well-preserved in the FK409 group. The 3-day survival rate was statistically better in the FK409 group (67%) than in the control group (14%). CONCLUSIONS: FK409 appears to have protective effects during extended liver resection with ischemia. (J Am Coll Surg 2001;193:264-271. (C) 2001 by the American College of Surgeons).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:51:59