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Titolo:
Expression of estrogen receptor (ER)-alpha and-beta immunoreactivity in hippocampal cell cultures with special attention to GABAergic neurons
Autore:
Su, JD; Qiu, J; Zhong, YP; Li, XY; Wang, JW; Chen, YZ;
Indirizzi:
Mil Med Coll 2, Dept Physiol, Shanghai 200433, Peoples R China Mil Med Coll 2 Shanghai Peoples R China 200433 i 200433, Peoples R China Mil Med Coll 2, Inst Neurosci, Shanghai 200433, Peoples R China Mil Med Coll 2 Shanghai Peoples R China 200433 i 200433, Peoples R China Chinese Acad Sci, Shanghai Inst Physiol, Key Lab Neurobiol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 5, volume: 65, anno: 2001,
pagine: 396 - 402
SICI:
0360-4012(20010901)65:5<396:EOER(A>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; LOCALIZATION; ALPHA; PROTEIN; ESTRADIOL; CALCIUM; BINDING;
Keywords:
hippocampus; estrogen receptor; astrocyte; GABA; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Qiu, J Mil Med Coll 2, Dept Physiol, Shanghai 200433, Peoples R China Mil Med Coll 2 Shanghai Peoples R China 200433 3, Peoples R China
Citazione:
J.D. Su et al., "Expression of estrogen receptor (ER)-alpha and-beta immunoreactivity in hippocampal cell cultures with special attention to GABAergic neurons", J NEUROSC R, 65(5), 2001, pp. 396-402

Abstract

This study investigated the expression patterns of estrogen receptor-alpha(ER alpha) and -beta (ER beta) in the cultured hippocampal cells of neonatal rats by combined application of cell culture and immunocytochemistry. The results revealed that the expression difference between ER alpha and ER beta seemed to be not obvious in the cultured hippocampal cells of neonatal rats. Moreover, immunoreactivity for either ER alpha or ER beta was observed to be localized in the majority of not only neurons but also astrocytes. The coexpression of both ER alpha and ER beta in the same individual cell was also demonstrated by the double-label immunocytochemistry. Western blot analysis showed that immunoreactivity for ER in the neonatal hippocampal tissues was much higher than in the adult (became rather weak), although there was not such a great difference of immunoreactivity for ER beta. The dataalso provide direct evidence for the expression of ER subtypes within GABAergic neurons in hippocampal cell cultures and suggest that estrogen's effect on the hippocampus may be mediated at least in part by its ER-containingGABAergic neurons. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 18:26:49